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Recombinant Mouse Complement component C1q receptor (Cd93), partial

Recombinant Mouse Complement component C1q receptor (Cd93), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd93

Uniprot NO.

O89103

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development.

Gene References into Functions

serum CD93 is a biomarker for allergic asthma PMID:29498549
The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases. We further demonstrated that stress-induced release of sCD93 is impaired by hyperglycemia. Study propose CD93 as an important component in glucometabolic regulation. PMID:27659228
soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID:23272129
[review] CD93 regulates inflammation as demonstrated in a murine model of cerebral ischemia reperfusion-induced injury and peritonitis; recent data suggests that a soluble form of CD93 regulates the inflammatory function of monocytes/ macrophages. PMID:22206251
these data suggest that cell-associated CD93 regulates leukocyte recruitment and complement activation during murine peritonitis. PMID:21849679
we speculate that CD93-neuroprotection is mediated via suppression of the neuroinflammatory response through downregulation of CCL21. PMID:20439917
Cd93 may be an autoimmune susceptibility gene residing within the Idd13 locus, which plays a role in regulating absolute numbers of CD4(+) NKT cells. PMID:20387063
Data demonstrate that inflammation triggers release of sCD93 in vivo, identify the inflammatory macrophage as a source of sCD93, and provide insight into the mechanism by which CD93 contributes to engulfment of apoptotic cells. PMID:19603257
Impaired uptake of apoptotic cells in C1qRp-deficient mice indicates that the C1qRp receptor may contribute to the removal of dying cells in vivo. PMID:15004139
CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches. PMID:19228948
These data suggest that AA4.1 is a cell surface marker that can identify the earliest lymphohematopoietic progenitors in mouse development. PMID:19458045

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in lung, heart and bone marrow. Expressed at lower level in ovary, whole embryo and fetal liver. Not detected in brain, adult liver or thymus. Highly expressed in peritoneal cavity and bone marrow macrophages. Not detected in epithelial cells.

Database Links

UNIGENE: Mm.681

KEGG: mmu:17064

STRING: 10090.ENSMUSP00000096876

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