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Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial

Recombinant Mouse Collagen alpha-2 (IV) chain (Col4a2), partial

Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Col4a2

Uniprot NO.

P08122

Alternative Names

Col4a2Collagen alpha-2(IV) chain [Cleaved into: Canstatin]

Species

Mus musculus (Mouse)

Source

Baculovirus

Expression Region

184-1707

Target Protein Sequence

GEPGEPG LVGYQGPPGR PGPIGQMGPM GAPGRPGPPG PPGPKGQPGN RGLGFYGQKG EKGDIGQPGP NGIPSDITLV GPTTSTIHPD LYKGEKGDEG EQGIPGVISK GEEGIMGFPG IRGFPGLDGE KGVVGQKGSR GLDGFQGPSG PRGPKGERGE QGPPGPSVYS PHPSLAKGAR GDPGFQGAHG EPGSRGEPGE PGTAGPPGPS VGDEDSMRGL PGEMGPKGFS GEPGSPARYL GPPGADGRPG PQGVPGPAGP PGPDGFLFGL KGSEGRVGYP GPSGFPGTRG QKGWKGEAGD CQCGQVIGGL PGLPGPKGFP GVNGELGKKG DQGDPGLHGI PGFPGFKGAP GVAGAPGPKG IKGDSRTITT KGERGQPGIP GVHGMKGDDG VPGRDGLDGF PGLPGPPGDG IKGPPGDAGL PGVPGTKGFP GDIGPPGQGL PGPKGERGFP GDAGLPGPPG FPGPPGPPGT PGQRDCDTGV KRPIGGGQQV VVQPGCIEGP TGSPGQPGPP GPTGAKGVRG MPGFPGASGE QGLKGFPGDP GREGFPGPPG FMGPRGSKGT TGLPGPDGPP GPIGLPGPAG PPGDRGIPGE VLGAQPGTRG DAGLPGQPGL KGLPGETGAP GFRGSQGMPG MPGLKGQPGF PGPSGQPGQS GPPGQHGFPG TPGREGPLGQ PGSPGLGGLP GDRGEPGDPG VPGPVGMKGL SGDRGDAGMS GERGHPGSPG FKGMAGMPGI PGQKGDRGSP GMDGFQGMLG LKGRQGFPGT KGEAGFFGVP GLKGLPGEPG VKGNRGDRGP PGPPPLILPG MKDIKGEKGD EGPMGLKGYL GLKGIQGMPG VPGVSGFPGL PGRPGFIKGV KGDIGVPGTP GLPGFPGVSG PPGITGFPGF TGSRGEKGTP GVAGVFGETG PTGDFGDIGD TVDLPGSPGL KGERGITGIP GLKGFFGEKG AAGDIGFPGI TGMAGAQGSP GLKGQTGFPG LTGLQGPQGE PGRIGIPGDK GDFGWPGVPG LPGFPGIRGI SGLHGLPGTK GFPGSPGVDA HGDPGFPGPT GDRGDRGEAN TLPGPVGVPG QKGERGTPGE RGPAGSPGLQ GFPGISPPSN ISGSPGDVGA PGIFGLQGYQ GPPGPPGPNA LPGIKGDEGS SGAAGFPGQK GWVGDPGPQG QPGVLGLPGE KGPKGEQGFM GNTGPSGAVG DRGPKGPKGD QGFPGAPGSM GSPGIPGIPQ KIAVQPGTLG PQGRRGLPGA LGEIGPQGPP GDPGFRGAPG KAGPQGRGGV SAVPGFRGDQ GPMGHQGPVG QEGEPGRPGS PGLPGMPGRS VSIGYLLVKH SQTDQEPMCP VGMNKLWSGY SLLYFEGQEK AHNQDLGLAG SCLARFSTMP FLYCNPGDVC YYASRNDKSY WLSTTAPLPM MPVAEEEIKP YISRCSVCEA PAVAIAVHSQ DTSIPHCPAG WRSLWIGYSF LMHTAAGDEG GGQSLVSPGS CLEDFRATPF IECNGGRGTC HYFANKYSFW LTTIPEQNFQ STPSADTLKA GLIRTHISRC QVCMKNL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Gene References into Functions

alpha2(IV)NC1 domain has a role in regulating tumor cell behavior PMID:15743801
These results indicate that SOX9 is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis. PMID:17525254

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Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane.

Protein Families

Type IV collagen family

Database Links

UNIGENE: Mm.181021

KEGG: mmu:12827

STRING: 10090.ENSMUSP00000033899

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