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Recombinant Mouse Collagen alpha-1 (VII) chain (Col7a1), partial

Recombinant Mouse Collagen alpha-1 (VII) chain (Col7a1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Col7a1

Purity

>85% (SDS-PAGE)

Target Names

Col7a1

Uniprot NO.

Q63870

Alternative Names

Col7a1Collagen alpha-1(VII) chain; Long-chain collagen; LC collagen

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

25-2944

Target Protein Sequence

QPRDRV TCTRLYAADI VFLLDGSSSI GRSNFREVRG FLEGLVLPFS GAASAQGVRF ATVQYSDDPQ TEFGLDTLGS GSDTIRAIRE LSYKGGNTRT GAALHHVSDR VFLPRLTRPG VPKVCILITD GKSQDLVDTA AQKLKGQGVK LFAVGIKNAD PEELKRVASQ PTSDFFFFVN DFSILRTLLP LISRRVCTTA GGVPVTLPSD DTPSGPRDLV LSEPSSQSLR VQWTAASGPV TGYKVQYTPL TGLGQPLPSE RQEVNIPAGE TSTRLQGLRP LTDYQVTVVA LYANSIGEAV SGTARTTAKE GLELSLQNIT SHSLLVAWRR VPGANGYRVT WRDLSGGPTQ QQDLSPGQGS VFLDHLEPGT DYEVTVSALF GHSVGPAASL TARTASSVEQ TLHPIILSPT SILLSWNLVP EARGYRLEWR RESGLETPQK VELPPDVTRH QLDGLQPGTE YRLTLYTLLE GREVATPATV VPTGLEQLVS PVMNLQAIEL PGQRVRVSWN PVPGATEYRF TVRTTQGVER TLLLPGSQTT FDLDDVRAGL SYTVRVSARV GAQEGDASIL TIHRDPEAPL VVPGLRVVAS DATRIRVAWG LVPGASGFRI SWRTGSGPES SRTLTPDSTV TDILGLQPST SYQVAVSALR GREEGPPVVI VARTDPLGPV RRVHLTQAGS SSVSITWTGV PGATGYRVSW HSGHGPEKSL LVSGDATVAE IDGLEPDTEY IVRVRTHVAG VDGAPASVVV RTAPEPVGSV SKLQILNASS DVLRVTWVGV PGATSYKLAW GRSEGGPMKH RILPGNKESA EIRDLEGGVS YSVRVTALVG DREGAPVSIV ITTPPATPAL LETLQVVQSG EHSLRLRWEP VPGAPGFRLH WQPEGGQEQS LTLGPESNSY NLVGLEPATK YQVWLTVLGQ TGEGPPRKVT AYTEPSHIPS TELRVVDTSI DSVTLTWTPV SGASSYILSW RPLRGTGQEV PRAPQTLPGT SSSHRVTGLE PGISYVFSLT PIQSGVRGSE ISVTQTPACS HGPVDVVFLL HATRDNAHNA EAVRRVLERL VSALGPLGPQ AAQVGLLTYS HRPSPLFPLN SSHDLGIILR KIRDIPYVDP SGNNLGTAVT TAHRYLLASN APGRRQQVPG VMVLLVDEPL RGDILSPIRE AQTSGLKVMA LSLVGADPEQ LRRLAPGTDP IQNFFAVDNG PGLDRAVSDL AVALCQAAVT IEPQTGPCAV HCPKGQKGEP GVTGLQGQAG PPGPPGLPGR TGAPGPQGPP GSTQAKGERG FPGPEGPPGS PGLPGVPGSP GIKGSTGRPG PRGEQGERGP QGPKGEPGEP GQITGGGGPG FPGKKGDPGP SGPPGSRGPV GDPGPRGPPG LPGISVKGDK GDRGERGPPG PGIGASEQGD PGLPGLPGSP GPQGPAGRPG EKGEKGDCED GGPGLPGQPG PPGEPGLRGA PGMTGPKGDR GLTGTPGEPG VKGERGHPGP VGPQGLPGAA GHPGVEGPEG PPGPTGRRGE KGEPGRPGDP AVGPGGAGAK GEKGEAGLPG PRGASGSKGE QGAPGLALPG DPGPKGDPGD RGPIGLTGRA GPTGDSGPPG EKGEPGRPGS PGPVGPRGRD GEAGEKGDEG IPGEPGLPGK AGERGLRGAP GPRGPVGEKG DQGDPGEDGR NGSPGSSGPK GDRGEPGPPG PPGRLVDAGI ESRDKGEPGQ EGPRGPKGDP GPPGVSGERG IDGLRGPPGP QGDPGVRGPA GDKGDRGPPG LDGRSGLDGK PGAPGPPGLH GASGKAGDPG RDGLPGLRGE HGPPGPPGPP GVPGKAGDDG KPGLNGKNGD PGDPGEDGRK GEKGDSGAPG REGPDGPKGE RGAPGNPGLQ GPPGLPGQVG PPGQGFPGVP GITGPKGDRG ETGSKGEQGL PGERGLRGEP GSLPNAERLL ETAGIKVSAL REIVDTWDES SGSFLPVPER RPGPKGDPGD RGPPGKEGLI GFPGERGLKG ERGDPGPQGP PGLALGERGP PGPPGLAGEP GKPGIPGLPG RAGGSGEAGR PGERGERGEK GERGDQGRDG LPGLPGPPGP PGPKVAIEEP GPGLAREQGP PGLKGAKGEP GSDGDPGPKG DRGVPGIKGD VGEPGKRGHD GNPGLPGERG VAGPEGKPGL QGPRGTPGPV GSHGDPGPPG APGLAGPAGP QGPSGLKGEP GETGPPGRGL PGPVGAVGLP GPPGPSGLVG PQGSPGLPGQ VGETGKPGPP GRDGSSGKDG DRGSPGVPGS PGLPGPVGPK GEPGPVGAPG QVVVGPPGAK GEKGAPGDLA GALLGEPGAK GDRGLPGPRG EKGEAGRAGG PGDPGEDGQK GAPGLKGLKG EPGIGVQGPP GPSGPPGMKG DLGPPGAPGA PGVVGFPGQT GPRGETGQPG PVGERGLAGP PGREGAPGPL GPPGPPGSAG APGASGLKGD KGDPGAGLPG PRGERGEPGV RGEDGHPGQE GPRGLVGPPG SRGEQGEKGA AGAAGLKGDK GDSAVIEGPP GPRGAKGDMG ERGPRGIDGD KGPRGESGNP GDKGSKGEPG DKGSAGSIGV RGLTGPKGEP GAAGIPGEPG APGKDGIPGF RGDKGDIGFM GPRGLKGEKG IKGTCGRDGE RGDKGEAGFP GRPGLAGKKG DMGEPGLPGQ SGAPGKEGLI GPKGDRGFDG QSGPKGDQGE KGERGPPGVG GFPGPRGNDG SSGPPGPPGG VGPKGPEGLQ GQKGERGPPG ESVVGAPGAP GTPGERGEQG RPGPAGPRGE KGEAALTEDD IRDFVRQEMS QHCACQGQFI ASGSRPLPGY AADTAGSQLH HVPVLRVSHV EEEGQVPPED DDDFSEYSVY SVEDYQEPEV PWDGEAEIKG WDQRGSDLCS LPLDEGSCTA YTLRWYHRAV PGGTACHPFV YGGCGGNANR FGTREACERR CPPQGVHSQK TGAA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.

Gene References into Functions

Biophysical characterization of a pathogenic type VII collagen mutant is presented. The pathogenic mutant lowers thermal stability of the type VII collagen domain. Due to unfolding, protease cleavage sites in the domain become accessible. PMID:27989960
specifically binds and sequesters the innate immune activator cochlin in the lumen of lymphoid conduits PMID:29305555
miR-29 Regulates COL7A1 in Recessive Dystrophic Epidermolysis Bullosa, directly through targeting its 3' untranslated region at two distinct seed regions and indirectly through targeting an essential transcription factor required for basal COL7A1 expression, SP1 PMID:27328306
autoantibodies to COL7, independent of the targeted epitopes, induce blisters both ex vivo and in vivo PMID:25689103
The cystine knot is N-terminal to the collagen triple helix in in collagen type VII and IX and therefore probably impedes unfolding of the collagen triple helix from the N terminus. PMID:24385431
COL7A1 is required for re-epithelialization through organization of laminin-332 at the dermal-epidermal junction during wound healing. PMID:23867500
COL7 regulates ameloblast differentiation and is essential for the formation of Tomes' processes. PMID:22940071
Tissue-bound, but not circulating, complement-fixing COL7-specific autoantibodies are associated with T helper type (Th)1 cell type cytokine expression and response in mice seusceptible to epidermolysis bullosa acquisita. PMID:21967893
An interaction of mvWFA2 with its neighboring domain mFNIII-9 was characterized with NMR spectroscopy and SPR PMID:21570975
transforming growth factor beta1 stimulation of Col7a1 transcription is dependent on a putative interaction between Smads and AP1. PMID:14675198
single amino acid substitutions in procollagen VII alter its self-assembly PMID:15509587
All mice developed circulating IgG autoantibodies that recognized type VII collagen and bound to the lamina densa of the dermal-epidermal junction[type VII collagen] PMID:16920988
Results describe the generation of a collagen VII alpha 1 hypomorphic mouse that serves as an immunocompetent animal model for dystrophic epidermolysis bullosa. PMID:18382769