Recombinant Mouse Collagen alpha-1 (II) chain (Col2a1), partial

1. this study's findings indicate that endothelial Del-1 not influence atherosclerosis development in ApoE(-/-) mice PMID:28796274
2. Overexpression of Dlx2 enhances early chondrocyte differentiation by increasing accumulation of Col2alpha1, type II collagen and aggrecan, but interferes later stages of chondrocyte differentiation through inhibiting MMP13 expression. PMID:29787757
3. Detection of transcripts of Collagen type2 A1 (Col2a1) revealed that both e trabecular cartilageand the anterior part of the hypophyseal cartilage developing anterior to the persistent epithelial stalk of the anterior lobe of the pituitary gland were suppressed in the Foxc1(ch/ch) . PMID:29322554
4. found bone destruction and bone loss phenotype in vertebral bone in beta-catenin(Col2CreER) KO mice PMID:29230102
5. Kartogenin effectively increased the expression of Col II and aggrecan in hNPCs and slowed the degeneration of intervertebral discs stimulated by IL-1b and TNF-a PMID:29207013
6. These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1. PMID:27881681
7. this study shows role of Del-1 in the regulation of platelet-monocyte interplay and the subsequent heterotypic aggregate formation in the blood-mediated inflammatory reaction in islet transplantation PMID:26676803
8. Alpha-tectorin and beta-tectorin crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus. PMID:26806019
9. Col2 expression was seen in the prehypertrophic zone of the mandibular condyle cartilage. PMID:26362410
10. Rspo2 activates Wnt/beta-catenin signaling to reduce Col2a1 and Sox9 and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage PMID:27012200
11. The MC13 mutation in Col2a1 causes an incompletely penetrant splicing defect. PMID:25541700
12. The mutant G1170S Col2a1 gene in mice clearly alters the transgenic murine phenotype and cartilage matrix homeostasis. PMID:24168833
13. Data indicate that tamoxifen decreased collage type II COL2A1 by activating matrix metallopeptidases MMP-2/13 expression. PMID:25703139
14. a mouse of model of spondyloepiphyseal dysplasia is associated with the R992C substitution in collagen II PMID:25451152
15. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA during scleral chondrogenesis accompany myopia development. PMID:25684979
16. Results indicate the ability of type II collagen (CII) to generate CII-specific anterior chamber-associated immune deviation (ACAID)-mediated immune tolerance in vivo and in vitro in both DBA/1 mice and C57BL/6 mice. PMID:25211510
17. expression of the Col2a1 IIC splice form may have a regulatory function in controlling alternative splicing of exon 2 to generate defined proportions of IIA, IID and IIB procollagen isoforms during cartilage development PMID:24735995
18. regulates Mac-1-mediated complement-dependent phagocytosis PMID:24352615
19. characterization of the Col2a1(+ex2) mice has surprisingly shown that disruption of alternative splicing does not affect overt cartilage formation PMID:24113490
20. Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PMID:24475193
21. Type II collagen induces peripheral tolerance in BALB/c mice via the generation of CD8+ T regulatory cells PMID:23133648
22. An autoimmune response to CII can disrupt articular cartilage, particularly that of the small joints, and the subsequent integrity of the cartilage depends on a balance between breakdown and repair. PMID:23239042
23. Lef1 mediated looping between promoter and 3' UTR under the permissive chromatin architecture upregulates Col2a1 expression in primary chondrocytes. PMID:22815835
24. A mouse model with a Ser1386Pro mutation of the Col2a1 C-propeptide domain that results in abnormal collagen processing and phenotypic features consistent with spondyloepiphyseal dysplasia congenita and secondary osteoarthritis has been established. PMID:22028304
25. SOX9 regulates chondrocyte differentiation, proliferation.. It directly transactivates Col2a1 enhancing this gene's expression in immature/proliferating chondrocytes. PMID:22072985
26. B cell-reactive epitopes on collagen II (CII)are largely shared between human rheumatoid arthritis and rodent CII-induced arthritis. PMID:21940677
27. beta2-adrenergic receptors inhibit the expression of collagen type II in growth plate chondrocytes by stimulating the AP-1 factor Jun-B. PMID:21177286
28. Data show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced transcript of Col2a1, is expressed in the prechordal plate and the anterior definitive endoderm. PMID:20730911
29. Down-regulation of Col2a1 is associated with autoimmune type 1 diabetes mellitus. PMID:20414703
30. Study identified 57 novel mutations including missense changes in both COL2A1 and COL11A1. PMID:20513134
31. The relative expressions of type IIB to type IIA procollagens are good markers to define the differentiation state of chondrocytes. PMID:20129696
32. decreased production in LPS-treated chondrocytes treated with low molecular mass hyaluronan PMID:19710088
33. a new long form cooperates with Sox9 to activate the type II collagen gene. (Lc-maf protein) PMID:12381733
34. Snail family members, Snail (Sna) and Slug (Slugh), are involved in chondrocyte differentiation by controlling the expression of type II collagen (Col2a1) and aggrecan. PMID:12917416
35. A missense mutation in the Col2a1 gene has been discovered, resulting in a phenotype of spondyloepiphyseal dysplasia congenita. Adult homozygous mutant animals have shortened noses, dysplastic vertebrae, femora, and tibias, retinoschisis and hearing loss. PMID:12968670
36. Col2a1 mutant mice have a complete absence of mature type II collagen in the homozygote cartilage and an insufficiency of type II collagen in the heterozygote cartilage PMID:14614991
37. MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development PMID:15778499
38. cis elements in the COL2A1 gene modulate the cell type-specific alternative splicing switch of exon 2 during cartilage development PMID:16076844
39. IGF-I from cells expressing procollagen type IIalphaI regulates bone accretion that occurs during postnatal growth period. PMID:17519362
40. this novel form of combined pituitary hormone deficiency is characterized by the perturbation of the hypothalamus-pituitary growth axis, associated with retarded chondrocyte development and enchondral ossification in the epiphyseal growth plate PMID:17591962
41. Type II collagen proteolysis is an important determinant for the skeletal outgrowth in mouse embryos through modulation of chondrocyte survival and cartilagenous growth. PMID:17652426
42. Data demonstrate that conditional ablation of the Kif3a or Pkd1 genes encoding primary cilium/intraflagellar transport-associated proteins using type II collagen-specific Cre transgenic strain results in a severe form of polycystic kidney disease in mice. PMID:18579360
43. C-propeptide mutation could interrupt the normal assembly and secretion of Type II procollagen trimers, resulting in a buildup of proalpha1(II) chains in the RER and a reduced rate of matrix synthesis. PMID:18678883
44. MT1-MMP activity in the type II collagen-expressing cells of the skeleton rescues not only diminished chondrocyte proliferation, but also results in amelioration of the severe skeletal dysplasia associated with MT1-MMP deficiency. PMID:19419317
45. Data reveal that COL2 is attacked at a susceptible peptide bond at the surface of developing articular cartilage canals, and is cleaved by MMP-13. PMID:19441084

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UNIGENE: Mm.2423

KEGG: mmu:12824

STRING: 10090.ENSMUSP00000023123