Recombinant Mouse Chromodomain-helicase-DNA-binding protein 4 (Chd4), partial

1. results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues PMID:29795351
2. Direct CHD4-mediated repression of skeletal and smooth muscle myofibril isoforms is required for normal cardiac sarcomere formation, function, and embryonic survival early in gestation. Unique CHD4 binding sites are found in smooth muscle myosin heavy chain, fast skeletal alpha-actin, and the fast skeletal troponin complex genes. PMID:29891665
3. RNA interference identifies CHD4 as an essential gene in regulating breast cancer growth. PMID:27779108
4. Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system. PMID:27140400
5. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription. PMID:27414498
6. this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state PMID:28092372
7. preservation of the identity of the two striated muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD. PMID:27166947
8. complex lacking CHD4 that has HDAC activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity. PMID:27235397
9. CHD4 depletion modulates expression of acute myeloid leukemia cell genes that regulate tumor formation in vivo and colony formation in vitro. PMID:26265695
10. CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed. PMID:26116663
11. Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells PMID:24348274
12. Chd4, interacting with Hdac1/2, cooperates with its related proteins Kap1 and Cbx1 to bind at -207/-148 of the Sox9 promoter. PMID:23519980
13. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters. PMID:23796711
14. The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 required specifically for Polycomb group (PcG)-mediated suppression of the key astrogenic marker gene GFAP. PMID:23624931
15. Gata3/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation. PMID:23471993
16. In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis PMID:23284307
17. Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment. PMID:22290435
18. activity of the Mi-2beta nucleosome-remodeling and histone-deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid lineage-determining proteins. PMID:22080921
19. downregulated expression in T cells following treatment with bis(tri-n-butylin)oxide (TBTO), an immunotoxic organotin PMID:19552622
20. repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex PMID:16574654
21. Mi-2beta is essential for the reprogramming of basal cells to the follicular and, subsequently, hair matrix fates. PMID:17360773
22. during definitive erythropoiesis, gamma-globin gene expression is silenced, in part, by binding a protein complex containing GATA-1, FOG-1, and Mi2 at the -566/-567 GATA sites of the proximal gamma-globin promoters PMID:18347053
23. Data show that Mi-2beta provides the hematopoietic system with immune cell capabilities as well as with an extensive regenerative capacity. PMID:18451107

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UNIGENE: Mm.333388

KEGG: mmu:107932

STRING: 10090.ENSMUSP00000060054