Recombinant Mouse Cell adhesion molecule-related/down-regulated by oncogenes (Cdon), partial

1. Cdon deficiency causes hyperactive Wnt signaling leading to aberrant intercellular coupling and cardiac fibrosis. PMID:28154134
2. Mutation in the Cdon gene is associated with congenital nevus development. PMID:27155367
3. Study assessed the role of the Shh receptor Cdon in the development of ventral tegmental area and substantia nigra pars compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry. PMID:27419218
4. Results suggest that a promyogenic cell adhesion molecule Cdo signaling is critical for Inward rectifier potassium channel Kir2.1 activities in the induction of myogenic differentiation. PMID:27380411
5. PKN2 formed complexes with Cdo, APPL1 and AKT via its C-terminal region and this interaction appeared to be important for induction of AKT activity as well as myoblast differentiation. PMID:27763641
6. that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development PMID:26988125
7. Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. PMID:24244464
8. Cx43 physically interacts with Cdo to form dynamic complexes during myoblast differentiation PMID:22930637
9. Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK PMID:21820049
10. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID:21802063
11. the Integrin/FAK signaling pathway regulates the expression of the promyogenic factors, Cdo, MyoD and Cdc42 which are required for myoblast differentiation PMID:21397010
12. Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly. PMID:21183473
13. The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt. PMID:20484574
14. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID:20519495
15. CDO has a role in regulation of myogenic bHLH factors and skeletal muscle development PMID:15572127
16. CdO promotes neuronal differentiation. PMID:16648472
17. Functions a component of multiprotein cell surface complex to promote myogenesis. PMID:17074887
18. Gas1 and Cdo cooperate to promote Shh signaling during neural tube patterning, craniofacial, and vertebral development PMID:17504941
19. Cdon expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice. PMID:18721461
20. a conserved intracellular signaling mechanism initiated by Cdo regulates the activities of tissue-specific bHLH factors and therefore functions as a key regulator of differentiation of several different cell lineages PMID:19244314
21. The findings show that Cdo is required for normal eye development and is required for normal expression of patterning genes in both the ventral and dorsal domains. PMID:19754878

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UNIGENE: Mm.80509

KEGG: mmu:57810

STRING: 10090.ENSMUSP00000045547