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Recombinant Mouse Cdc42-interacting protein 4 (Trip10)

Recombinant Mouse Cdc42-interacting protein 4 (Trip10)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Trip10

Purity

>85% (SDS-PAGE)

Target Names

Trip10

Uniprot NO.

Q8CJ53

Alternative Names

Trip10; Cip4Cdc42-interacting protein 4; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-603

Target Protein Sequence

MDWGTELWDQ FEVLERHTQW GLDLLDKYVK FVKERAEVEQ AYAKQLRSLV KKYLPKRPTK DDPEVKFSQQ QSFVQLLQEV NDFAGQRELV AESLGIRVCL ELAKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK AAHTAERLDQ DINATKADVE KAKQQAHLRN HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELQ VVPIIGKCLE GMKVAAESVD AKNDSQVLIE LHKSGFARPG DLEFEDFSQV INRVPSDSSL GTPDGRPELR AASSRSRAKR WPFGKKNKPR PPSLSLLGGH LPSTLSDGPS SPRSGRDPLA ILSEISKSVK PRLASFRSFR GGRGTVATED FSHLPPEQQR KRLQQQLEER NRELQKEEDQ REALKKMKDV YEKTPQMGDP ASLEPRIAET LGNIERLKLE VQKYEAWLAE AESRVLSNRG DSLSRHARPP DPPTTAPPDS SSSSTNSGSQ DNKESSSEEP PSEGQDTPIY TEFDEDFEEP ASPIGQCVAI YHFEGSSEGT VSMSEGEDLS LMEEDKGDGW TRVRRKQGAE GYVPTSYLRV TLN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling.

Gene References into Functions

CIP4 silencing can efficiently alleviate Streptozotocin-induced pulmonary fibrosis in mice, perhaps through suppressing Wnt/GSK-3beta/beta-catenin signaling. PMID:28720386
CIP4 coordinates with phospholipids and actin-associated proteins to localize to the protruding edge and produce actin ribs and veils. PMID:23572514
CIP4 is a new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production. PMID:23881916
Data suggest that down-regulation of CIP4 in osteosarcoma changes cell morphology (reduces actin; alters cytoskeleton), inhibits primary tumor growth, impairs invasiveness and migration of tumor cells, delays metastasis, and prolongs survival time. PMID:22920438
In primary cortical neurons CIP4 is concentrated specifically at the tips of extending lamellipodia and filopodia, instead of endosomes as in other cell types. PMID:22361215
Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner. PMID:21299869
results demonstrate an important role for CIP4 in integrin-dependent T cell-dependent antibody responses and germinal center formation PMID:20805498
The studies demonstrate a physiological role for CIP4 in endocytosis leading to a whole animal phenotype. PMID:19920150
Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms (CIP4) PMID:12054674