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Recombinant Mouse Caspase recruitment domain-containing protein 10 (Card10), partial

Recombinant Mouse Caspase recruitment domain-containing protein 10 (Card10), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Card10

Uniprot NO.

P58660

Alternative Names

Card10; Bimp1Caspase recruitment domain-containing protein 10; Bcl10-interacting MAGUK protein 1; Bimp1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1021

Target Protein Sequence

MQGRADAGEA DEEAGAGSGS EAEEDALWER IEGVRHRLTR ALNPAKLTPY LRQCRVLDEQ DEEEVLSTYR FPCRANRTGR LIDILRCRGK RGFEAFLEAL EFYYPEHFTL LTGQEPAQRC SMILDEEGPE GLTQFLMTEV RRLREARKSQ LHREQQLQAR GRALEEERAG LEQRLREQQQ AQERCQRLRE DWEAGSLELL RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK VSRLEEECAL LRRARGPPPG AEEKEREPDG ADLLSELRAE NQRLTASLQE LQEGLQQEMS RPGAAGSERI LLDILEHDWR EAQDSRQELC QKLHAVQGEL QWAEELRDKY LQEMEDLRLK HRTLLKDCDL YKHRMATVLA QLEEIEKERD QAIQSRDRIQ LQYSQSLIEK DQYRKQVRGL EAERDELLTT VTSLEGTKAM LEAQLQRTQG GSCLKACASS HSLCSNLSST WSLSEFPSPL GGPEATGEAG GSEPHTSEEA TDSEKEINRL SILPFPPSAG SILRRQREED PEPPKRSFSS MSDITGSVTL KPWSPGLSSS SSSDSVWPLG KPEGLLARGC GLDFLNRSLA IRVSGWSPPA GLDPQDKSPD SMPGLGDRWS GAVVRRVLSG PGSARTEQKE PRAEGTGLEG AGLEAEAQQR TLPWNQSSTL PFLLDSKACH SFHEALDAWA KGPGAEPFYI RANFSLPERS DPHALCVKAQ EILRLVDPAH KRRQEWFCTR VDTLTLRDLD RGTVPNYQRA QQLLEVQEKY LISSRHRSPR SNLKKRALGL VRPKPAGGTA GDSAEQLPAE PCSELERSLK PYSLVRPLLV SALRPVVLLP ECLAPRLIRN LLDLPSSRLD FQVCPAESLS GEEQCTSSAP GAPKAWPATA GLGSRIRAIQ ESVGKKHCLL ELGARGVREL VHSEVYPIVI HVEVTEKNVR EIRGLLGRPG WRDSELLRQC RGSEQWLWGL PCSWVQVPAH AWGHAEELAK VVRGRILQEQ ARLVWVERGS SRGGSGSSSE A
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Activates NF-kappa-B via BCL10 and IKK.

Gene References into Functions

CARMA3 is gradually turned over following vesicular stomatitis virus infection, which may serve as a mechanism to turn off NF-kB activation, it releases MAVS to form functional aggregates to induce interferon regulatory factor 3 activation. PMID:26947079
CARMA3 is critical for the initiation of allergic airway inflammation. PMID:26041536
Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3.Bcl10.MALT1 signalosome PMID:21041303
the type 1 receptor for angiotensin II utilizes the CARMA3-Bcl10-MALT1 signalosome for activation of NF-kappaB in endothelial and vascular smooth muscle cells, thereby inducing pro-inflammatory signals within the vasculature PMID:20605784
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in hepatocytes. PMID:17101977
Together, results provide the genetic evidence that CARMA3 is required for G protein-coupled receptor-induced NF-kappaB activation. PMID:17438001
Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID:18757306
components of the CBM complex, Carma3, Bcl10, and Malt1 are key mediators of the CXCL8/IL8-induced NFkappaB activation and VEGF up-regulation. PMID:19112107