Recombinant Mouse Caspase-7 (Casp7)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Casp7

Uniprot NO.

P97864

Alternative Names

Casp7; Lice2; Mch3Caspase-7; CASP-7; EC 3.4.22.60; Apoptotic protease Mch-3; Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-23

Target Protein Sequence

TDDQDCAAE LEKVDSSSED GVD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death. Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9.

Gene References into Functions

Caspase 7 has a nonapoptic function that participates in normal spermatogenesis, but also displays apoptotic function in spermatogenic dysfunction. PMID:26643564
Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin. PMID:26253163
Optic nerve crush activated caspase-7 in retinal ganglion cells followed by cell death. Knockout of caspase-7 partially and significantly protected against ON injury-induced RGC loss. PMID:26306916
genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. PMID:26271098
In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway PMID:25162007
The scotopic electroretinography demonstrated that the ablation of the CASP7 in T17M RHO retina leads to significant preservation of the function of photoreceptors compared to controls. PMID:24664731
Data suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices. PMID:23713787
The results indicate a non-essential apoptotic role of caspase-7 in the PEK apoptosis but suggest also possible non-apoptotic functions for caspase-7 in tooth development. PMID:22858065
host activation of caspase-7 in response to pore formation represents an adaptive mechanism by which host cells can protect membrane integrity during Listeria monocytogenes infection PMID:22807671
An apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression is discussed. PMID:22464733
Our findings demonstrate for the first time a strong correlation between caspase-7 activity, normal brain development, and apoptotic DNA fragmentation in Casp3-/- mice. PMID:15525783
Our results show that in contrast to dermal fibroblasts and cortical neurons, sympathetic neurons express no detectable levels of caspase-7. PMID:16932756
proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis PMID:17646170
Caspase-7 was activated in the splenocytes of LPS-injected mice. CASP-7-deficient mice resist LPS-induced lymphocyte apoptosis & are protected from LPS-induced lethality independently of the excessive production of serum cytokines. PMID:19168786
results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against Legionella pneumophila PMID:19343209
In mid-gestational wounds, activation of apoptotic pathways may be mediated through effector caspase 7 signals with inactivation of PARP. PMID:19555972