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Recombinant Mouse Casein kinase I isoform delta (Csnk1d)

Recombinant Mouse Casein kinase I isoform delta (Csnk1d)

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Source
Conjugate
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Target Background

Product Details

Abbreviation

Csnk1d

Purity

>85% (SDS-PAGE)

Target Names

Csnk1d

Uniprot NO.

Q9DC28

Alternative Names

Csnk1d; Hckid; Casein kinase I isoform delta; CKI-delta; CKId; EC 2.7.11.1; Tau-protein kinase CSNK1D; EC 2.7.11.26

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-415

Target Protein Sequence

MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV SGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene References into Functions

CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h). PMID:29463694
Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm. PMID:29784789
the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit. PMID:27439882
Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta. PMID:28963394
Report temperature-compensated CKIdelta-dependent multi-site phosphorylation in mammals underlies temperature compensated phosphorylation in circadian clocks. PMID:28886336
Together, these findings suggest that CK1delta contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1. PMID:28125685
we conclude that APC/C(Cdh1) controls CK1 delta levels to balance proliferation and cell-cycle exit in the developing CNS PMID:25843713
CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi. PMID:24648492
this article reports the crystallization and structure determination of a new crystal form of casein kinase I delta belonging to space group P21. PMID:24100552
decreases in CKIdelta activity can contribute to the pathogenesis of migraine. PMID:23636092
REGgamma-deficient mice develop premature aging phenotypes that are associated with abnormal accumulation of casein kinase (CK)1delta and p53. Antibody array analysis identified CK1delta as a direct target of REGgamma. PMID:23766372
inactivating mutations in CK1delta impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo PMID:22235331
CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator PMID:20421981
These results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt-3a-dependent neuritogenesis. PMID:21422228
The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 and regulates Dnmt1 function by reducing the DNA-binding activity. PMID:20192920
physical interaction between PER and CKIdelta/epsilon required for circadian rhythm PMID:19948962
Results indicate that CKIdelta plays several roles in lymphocyte physiology. PMID:12924632
snapin is a new substrate of CK1delta PMID:17101137
The balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. PMID:18953287
generated mice with liver-specific disruption of CK1delta. In livers from these mice, daytime levels of nuclear PER proteins, and PER-CRY-CLOCK complexes were elevated. In vitro, the half-life of PER2 was increased by approximately 20%. PMID:19414593
The degradation rate of PER2, which is regulated by CKIepsilon/delta-dependent phosphorylation, was temperature-insensitive in living clock cells. PMID:19805222

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus.

Protein Families

Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily

Tissue Specificity

Expressed ubiquitously. However, kinase activity is not uniform, with highest kinase activity in splenocytes.

Database Links

UNIGENE: Mm.216227

KEGG: mmu:104318

STRING: 10090.ENSMUSP00000018274

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