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Recombinant Mouse Carbonic anhydrase 9 (Ca9), partial

Recombinant Mouse Carbonic anhydrase 9 (Ca9), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ca9

Purity

>85% (SDS-PAGE)

Target Names

Ca9

Uniprot NO.

Q8VHB5

Alternative Names

Ca9; Car9Carbonic anhydrase 9; EC 4.2.1.1; Carbonate dehydratase IX; Carbonic anhydrase IX; CA-IX; CAIX; Membrane antigen MN homolog

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Reversible hydration of carbon dioxide. Participates in pH regulation.

Gene References into Functions

Authors demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity. PMID:28692057
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors. PMID:26152355
constitutive activation of the NF-kappaB pathway in CAIX-depleted cells restored G-CSF secretion PMID:25623234
Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PMID:23441228
CA IX may directly or indirectly play novel functions in brain tissue. PMID:21547424
about half the CA-dependent muscular lactate flux occurs across the surface membrane, while the other half occurs across the membranes of the T tubuli PMID:21179203
Data show that CA9, GLUT1 and LOX mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1, but not LOX, in SCCVII tumors. PMID:21306648
a novel role for CA IX in the regulation of immunologic processes and digestion PMID:20573196
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach PMID:16245156
These results suggest that the loss of function of cytosolic CA II in the stomach of Car2-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium. PMID:16396925
CA9 may regulate ion and pH homeostasis within the developing embryo. PMID:16719910
CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response PMID:19074859
that expression of CA9 is regulated through both the HIF-1 and unfolded protein response hypoxia response pathways in vitro and in vivo. PMID:19564335