Recombinant Mouse Calcineurin subunit B type 1 (Ppp3r1)

1. Calcineurin B1 deficiency in glial cells impairs the small intestine and leads to malnutrition and eventual death in mice, suggesting that calcineurin plays a novel and important role in enteric glial cells. PMID:29709916
2. Expression of the RNA-binding protein, tristetraprolin (TTP) was down-regulated in response to calcineurin inhibition. PMID:29723192
3. Mice lacking Calcineurin B in CD11c(high)MHCII(+) cells (Cnb1 (CD11c) mice) spontaneously develop intestinal inflammation and are susceptible to induced colitis. PMID:29549257
4. data demonstrate that decreasing calcineurin activity in the amygdala increases anxiety-like behaviors and to some extent depression-like behaviors. PMID:24742621
5. necessary for the development of the smooth muscle wall of coronary arteries PMID:23946498
6. Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. PMID:23303818
7. intact calcineurin/NFAT signalling is critically required for p53 and senescence-associated mechanisms that protect against skin squamous cancer development PMID:20485437
8. Mechanistically, loss of Heart-specific CnB1 reduced expression of key Ca(2+)-handling genes that likely lead to arrhythmia and reduced contractility PMID:20037164
9. Calcineurin B1 is essential for positive selection during thymocyte development. PMID:15030770
10. gene expression of peroxisome proliferator-activated receptor gamma coactivator 1alpha and peroxisome proliferator-activated receptor alpha was reduced in the hearts of mice with cardiac-specific ablation of the Cn regulatory subunit. PMID:15262994
11. Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID:17237284
12. Deletion substantially reduced skeletal muscle degeneration and histopathology compared with the sarcoglycan-null genotype alone. PMID:17289669
13. the inhibition of Cnb1 in osteoblasts increases bone mass by directly increasing osteoblast differentiation and indirectly decreasing osteoclastogenesis PMID:17884821
14. results indicate that early calcineurin/NFAT signalling produces a developmental period of ERK hypersensitivity, allowing very weak signals to induce positive selection PMID:18046413
15. gene deficiency results in reduced responsiveness of macrophages to LPS PMID:19318421
16. Report impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. PMID:19700627

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UNIGENE: Mm.41840

KEGG: mmu:19058

STRING: 10090.ENSMUSP00000099944