Recombinant Mouse COUP transcription factor 1 (Nr2f1)

1. COUP-TFI expression is required for functional organization of the hippocampal septo-temporal longitudinal axis PMID:26813976
2. These data identify silencer elements of the Nr2f1-A830082K12Rik gene pair as new candidate loci for Waardenburg syndrome type 4. PMID:27585883
3. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons PMID:28694260
4. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. PMID:25922524
5. Findings provide evidence that Sp8 and another transcription factor, COUP-TF1, mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes PMID:23307639
6. a novel tissue-dependent coregulatory network for NR2F1, miR-140, and Klf9 in the inner ear PMID:24349493
7. odour deprivation, which is known to downregulate tyrosine hydroxylase expression in the olfactory bulb, also downregulates COUP-TFI in dopaminergic cells, indicating a correlation between tyrosine hydroxylase- and COUP-TFI-activity-dependent action. PMID:24227652
8. CoupTFI collaborates with retinoic acid signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis PMID:23472160
9. COUP-TFI and related NRs such as the COUPTFs and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene. PMID:23975195
10. Our data suggest that the non-protein coding locus Mcs1a regulates Nr2f1, which is a candidate modifier of differentiation, proliferation, and mammary cancer risk. PMID:23785296
11. study extends the pool of recognized putative AR targets and identifies a negatively regulated target of AR - COUP-TF1 - which could possibly play a role in human prostate cancer PMID:23056316
12. Exogenous expression of COUP-TFI in AS cells, in a dose-dependent fashion, leads to growth inhibition. PMID:23018522
13. LHbeta promoter activity is further regulated by the orphan nuclear receptors, chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and COUP-TFII). PMID:20797425
14. COUP-TFI controls the delicate balance between medial ganglionic eminence and caudal ganglionic eminence derived cortical interneurons by regulating intermediate progenitor divisions PMID:21430164
15. This study demonstrated that kallistatin expression is repressed by triiodothyronine and modulated by the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor 1 (COUP-TF1). PMID:21266512
16. COUP-TFI exerts critical areal and temporal control over the precise differentiation of CSMN during corticogenesis, thereby enabling the area-specific functional features of motor and sensory areas to arise. PMID:20133588
17. Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis. PMID:20007910
18. Novel and distinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differentiation of progenitor cells; COUP-TFs are crucial for dorsalization of the eye. PMID:20147377
19. we found that COUP-TFI and -TFII play roles in amacrine cell differentiation, and COUP-TFgamma has distinct expression pattern and roles during retinal development. PMID:19766631
20. Results suggest COUP-TFI is an important regulator of oligodendrocyte differentiation. PMID:14738874
21. analysis of COUP-TFI and COUP-TFII expression during development and functional maturation of the mouse inner ear PMID:15907456
22. In the marginal zone (MZ) of the cortex , the nuclear receptor COUP-TFI is localized in calbindin-positive cells and not in reelin-positive cells and suggested represses differentiation of Cajal-Retzius cells. PMID:16144621
23. Results show that COUP-TFI is required for proper axonal growth and guidance of all major forebrain commissures. PMID:17021036
24. COUP-TF1 is an important signaling molecule during vitamin A (Rol)-mediated very early stage of embryonic development. PMID:18177425

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UNIGENE: Mm.439653

KEGG: mmu:13865

STRING: 10090.ENSMUSP00000089036