Recombinant Mouse CD99 antigen (Cd99), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Cd99

Purity

>85% (SDS-PAGE)

Target Names

Cd99

Uniprot NO.

Q8VCN6

Alternative Names

Cd99; PilrlCD99 antigen; Paired immunoglobin-like type 2 receptor-ligand; PILR-L; CD antigen CD99

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.

Gene References into Functions

endothelial CD99 promotes leukocyte attachment to endothelium in inflamed vessels by a heterophilic ligand. In addition, CD99 binds to PILRs on neutrophils, an interaction that leads to increased shear resistance of the neutrophil attachment to ICAM-1. PMID:28223280
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. PMID:26101266
role in membrane trafficking of CD99L2 and in controlling transendothelial migration of leukocytes PMID:24133166
CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells. PMID:22350746
CD99L2 and CD99 are involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum PMID:17344467
These findings indicate that sialylated O-linked sugar structures on CD99 play an important role in the recognition of PILR. PMID:18209065
Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice. PMID:18250143
Mouse CD99 is expressed on mouse leukocytes as well as enriched at the endothelial cell borders. PMID:18923973

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

CD99 family

Tissue Specificity

Widely expressed with high levels in lung, spleen, thymus, liver and spinal chord. Expressed on leukocytes and endothelial cell contacts. Detected in a wide range of T-cells, including CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in periph

Database Links

UNIGENE: Mm.423040

KEGG: mmu:673094

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