Recombinant Mouse CD160 antigen (Cd160)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd160

Uniprot NO.

O88875

Alternative Names

Cd160; By55CD160 antigen; Natural killer cell receptor BY55; CD antigen CD160) [Cleaved into: CD160 antigen; soluble form]

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

28-160

Target Protein Sequence

GCI HVTSSASQKG GRLDLTCTLW HKKDEAEGLI LFWCKDNPWN CSPETNLEQL RVKRDPETDG ITEKSSQLVF TIEQATPSDS GTYQCCARSQ KPEIYIHGHF LSVLVTGNHT EIRQRQRSHP DFSHINGTLS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines.; The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.

Gene References into Functions

CD160 may represent a suitable target for immune intervention in the setting of transplantation to modulate allogeneic cytotoxic responses. PMID:27702550
CD160 functionally controls cytokine production by natural killer cells. PMID:25711213
During chronic infection the number of CD4(+) T cells expressing programmed death-1 and CD160 were greater over the time-course study than the other CD4(+) T-cell inhibitory ligands. PMID:23566283
CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection. PMID:23593209
soluble CD160, produced by mast cells, may have a role in T-cell-mast cell interactions in vivo PMID:21191401
Knockout Mice BALB C Mice C3H Mice F344 Rats K562 Cells Cultured Cells PMID:16177084
CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells PMID:16764942

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Subcellular Location

[CD160 antigen]: Cell membrane; Lipid-anchor, GPI-anchor.; [CD160 antigen, soluble form]: Secreted.

Tissue Specificity

Expressed in resting and activated NK cell subsets (at protein level). Expressed in resting NKT cells (at protein level). Expressed in activated CD8+ T cells (at protein level). Highly expressed in intraepithelial lymphocyte (IEL) subsets, particularly in

Database Links

UNIGENE: Mm.34693

KEGG: mmu:54215

STRING: 10090.ENSMUSP00000037466

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