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Recombinant Mouse C-terminal-binding protein 1 (Ctbp1)

Recombinant Mouse C-terminal-binding protein 1 (Ctbp1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ctbp1

Uniprot NO.

O88712

Alternative Names

Ctbp1C-terminal-binding protein 1; CtBP1; EC 1.1.1.-

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-441

Target Protein Sequence

MGSSHLLNKG LPLGVRPPIM NGPMHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRTTWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG IERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYS RYPPGVVSVA PTGIPAAVEG IVPSAMSLSH GLPPVAHPPH APSPGQTVKP EADRDHTSDQ L
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Gene References into Functions

validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development PMID:27752147
C-terminal binding protein 1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other forms of pulmonary hypertension PMID:27562971
CtBP1 protein is not essential for the formation of functional ribbon synapses in the retina. PMID:23687428
Study demonstrates differential regional and subcellular expression patterns for CtBP1 and CtBP2 in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. PMID:22745816
CtBp proteins repress transcription in a histone deacetylase dependent or independent manner. PMID:11864595
The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells. PMID:12082639
Mice harboring various combinations of Ctbp1 and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes PMID:12101226
Genetic knockout of Cbtp1 in mouse embryo fibroblasts upregulates several genes involved in apoptosis. PMID:14567915
Smad6 repressed bone morphogenetic protein-induced Id1 transcription through recruiting transcriptional corepressor C-terminal binding protein (CtBP). PMID:14645520
Mono-ADP-ribosylation of CtBP1/BARS inactivates its repressor function, which leads to the activation of genes that regulate neutral lipid storage. PMID:17538025
p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. PMID:18199542
basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis PMID:18391014
The regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs. PMID:18483224
CtBP knockout increases Bax transcription, ablates mitochondrial morphology and reduces mitochondrial activities PMID:19136938
CtBP1 expressed in human CD4(+) T cells crucially contribute to Th1/Th2 differentiation via selective down-regulation of IL-4 synthesis. PMID:19275882