Recombinant Mouse Bromodomain-containing protein 2 (Brd2)

1. these results provided evidence for a novel role of Brd2 in chronic inflammation and insulin resistance. PMID:27865874
2. Brd2 and Brd4 genetic transcription required for Th17 cell development and adaptive immunity. PMID:28262505
3. This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs. PMID:26804911
4. BRD2 is involved in the modulation of neuroinflammatory responses through PAI-1 and via the regulation of epigenetic reader BET protein PMID:26349765
5. DNA demethylation of the Brd2 promoter region induced Brd2 expression during differentiation of 3T3-L1 cells into adipocytes. PMID:25575605
6. Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes. PMID:24194944
7. A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. PMID:24146614
8. We conclude that Brd2 plays a critical, independent role in regulation of mitogenic response genes PMID:24319289
9. Data show that infection of macrophages with Listeria monocytogenes caused binding of the BET proteins Brd2, Brd3, and, most prominently, Brd4 to the Nos2 promoter. PMID:24248598
10. Identification of motif B of Brd2 as a dimerization domain involved in association to mitotic chromosomes and proper recognition of acetylated chromatin. PMID:22595521
11. Studies showed that although Brd2 mRNA is expressed in both the hippocampus and cerebellum, Brd2 protein only can be detected in the cerebellar Purkinje cells and not in hippocampal cells. PMID:21608014
12. Compared to the Brd2+/+ littermates, Brd2+/- males have a decreased clonic, and females a decreased tonic-clonic, seizure threshold. PMID:21887291
13. Data show that hypomorphic Brd2 shifts energy balance toward storage without causing glucose intolerance and may provide a novel model for obese metabolically healthy humans. PMID:19883376
14. may be involved in the transcriptional activities of genes involved in proliferation of the mammary epithelia during pregnancy PMID:12145330
15. The distinct patterns of Brd2 localization within the adult ovary supports a role for Brd2 in mitotic and possibly meiotic cell cycle regulation PMID:15112318
16. Brd2-deficient embryos could not be rescued by wild-type extraembryonic tissues PMID:19301389
17. In developing a mouse model deficient in Brd2, we find that Brd2 is required for the completion of embryogenesis and proper neural tube closure during development. PMID:19362612
18. Knockdown of Brd2 with shRNA promotes adipogenic differentiation of 3T3-L1 preadipocytes in vitro. PMID:19883376
19. Reduced Brd2 levels block macrophage infiltration of white adipose tissue in mice and inflammation-associated insulin resistance. PMID:19883376
20. Brd2 inhibits pancreatic beta cell growth and insulin transcription. PMID:19883376
21. Knockdown of Brd2 with shRNA protects 3T3-L1 adipocytes from TNF-alpha-induced insulin resistance. PMID:19883376
22. Brd2 co-represses PPAR-gamma in 3T3-L1 pre-adipocytes and inhibits adipogenesis. PMID:19883376
23. Brd2 deficiency causes extreme obesity but simultaneously protects against whole-body insulin resistance and Type 2 diabetes. PMID:19883376
24. The Brd2 gene is located on Chromosome 17, within a region syntenic to the human class II major histocompatibility locus, but appears to have no role in antigen processing; Brd2 is likely involved in signal transduction and transcription. PMID:11983150
25. Brd2 autophosphorylation activity is induced in mouse tissues (lung, kidney, brain, liver and heart) upon systemic treatment with the mitogens Epidermal Growth Factor or Phorbol 12-Myristate 13-Acetate. PMID:9528865

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UNIGENE: Mm.3444

KEGG: mmu:14312

STRING: 10090.ENSMUSP00000025193