Recombinant Mouse Bone sialoprotein 2 (Ibsp)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Ibsp

Purity

>85% (SDS-PAGE)

Target Names

Ibsp

Uniprot NO.

Q61711

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

17-324

Target Protein Sequence

FSMK NFHRRIKAED SEENGVFKYR PRYFLYKHAY FYPPLKRFPV QGGSDSSEEN GDGDSSEEEG EEEETSNEEE NNEDSEGNED QEAEAENSTL STLSGVTASY GAETTPQAQT FELAALQLPK KAGDAESRAP KVKESDEEEE EEEEEEENEN EEAEVDENEL AVNGTSTNST EVDGGNGSSG GDNGEEAEAE EASVTEAGAE GTTGGRELTS VGTQTAVLLN GFQQTTPPPE AYGTTSPPIR KSSTVEYGGE YEQTGNEYNN EYEVYDNENG EPRGDTYRAY EDEYSYYKGH GYEGYEGQNY YYHQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Gene References into Functions

Data indicate that BSP is present in the calcified fibrocartilage of murine entheses and suggest that BSP plays a regulatory role in this structure, influencing the growth of the calcified fibrocartilage in addition to the weakening of the tendon mechanical properties. PMID:26826499
Bone marrow ablation in BSP-/- mice is followed by a faster vascular and hematopoietic recolonization, along with lower medullary bone formation. Thus, lack of BSP affects the interplay between hematopoiesis, angiogenesis, and osteogenesis, maybe in part through higher expression of VEGF and the angiogenic SIBLING, OPN. PMID:27704558
a bone sialoprotein-null bone microenvironment affects the hematopoietic system both quantitatively and qualitatively PMID:25502698
full expression of either OPN or BSP is necessary for the anabolic effect of PTH at least in the ectopic calvaria injection model PMID:25160656
BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function. PMID:23183644
Lack of BSP affects both osteoclast formation and activity. PMID:20812227
bone sialoprotein has a role in neoplasm metastasis PMID:12963984
BSP gene transcription is autoregulated in part by a positive feedback on its own promoter. PMID:15020240
Bsp mRNA is expressed in developing testis cords and thus may contribute to testis differentiation PMID:15937924
BSP contributes to RANKL-mediated bone resorption by inducing osteoclastogenesis and osteoclast survival and decreasing osteoclast apoptosis PMID:16059638
Stimulation with EMD significantly (P < .01) enhanced mRNA expression of BSP up to 13.9-fold. PMID:18547835
studies provided direct evidence for the involvement of covalently bound phosphates on BSP in receptor mediated "outside-in" signaling via transmembrane tyrosine phosphorylation with concurrent effects on downstream gene expressions PMID:19518132