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Recombinant Mouse Bone morphogenetic protein 8B (Bmp8b)

Recombinant Mouse Bone morphogenetic protein 8B (Bmp8b)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Bmp8b

Uniprot NO.

P55105

Alternative Names

Bmp8bBone morphogenetic protein 8B; BMP-8B

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

261-399

Target Protein Sequence

TARPLKKKQL NQINQLPHSN KHLGILDDGH GSHGREVCRR HELYVSFRDL GWLDSVIAPQ GYSAYYCAGE CIYPLNSCMN STNHATMQAL VHLMKPDIIP KVCCVPTELS AISLLYYDRN NNVILRRERN MVVQACGCH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.

Gene References into Functions

Results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK. PMID:22579288

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Subcellular Location

Secreted.

Protein Families

TGF-beta family

Tissue Specificity

Expressed in testis. Expressed in decidual cells of the uterus and in trophoblast cells of the labyrinthine region of the placenta and in the inner root sheath of hair follicles of early postnatal skin. Expressed in the extraembryonic ectoderm in pregastr

Database Links

UNIGENE: Mm.439764

KEGG: mmu:12164

STRING: 10090.ENSMUSP00000002457

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