Recombinant Mouse Bile salt export pump (Abcb11), partial

1. Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems. PMID:29850541
2. mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins. PMID:25552583
3. expression repressed by estradiol in the late stages of pregnancy PMID:24729004
4. CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels. PMID:24399466
5. FXR regulates BSEP in an isoform-dependent and species-specific manner PMID:24002920
6. Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids. PMID:23764895
7. Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation. PMID:23139217
8. The authors show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2. PMID:22767443
9. Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice. PMID:22619174
10. hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation. PMID:22057277
11. Hepatic overexpression of Abcb11 in mice promotes diet-induced obesity and hypercholesterolemia; increased intestinal cholesterol absorption by hydrophobic bile acids might cause these features. PMID:21726512
12. bile salt export pump (BSEP) PMID:21195347
13. Atypical 3 alpha,6 beta,7 beta,12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid appears in spgp knockout mice PMID:12562825
14. regulation of Abcb11 may be important for the pathogenesis and treatment of steatohepatitis PMID:14570929
15. the effect of the D482G progressive familial intrahepatic cholestasis type 2 related mutation on BSEP function PMID:14672610
16. We conclude that gallstone-susceptible C57L/J mice demonstrate increased gene and canalicular membrane expression of Abcb11, however, taurocholate transport is functionally diminished. PMID:14724752
17. Elevated level of Mdr1 in Abcb11 knockout mice functions as an alternative pathway to transport bile acids PMID:16156672
18. Hepatic overexpression of Abcb11 increases the rate of cholesterol gallstone formation,likely due to increases in bile salt hydrophobicity but not because of alterations of other biliary lipid transporters. This strongly support Abcb11 as a Lith 1 gene. PMID:16341669
19. Hepatic expression of BSEP mRNA decreased after transplantation. PMID:18551070
20. In the liver, histone H3 in the proximal promoter of Bsep is hyperacetylated, whereas acetylation in the kidney and cerebrum is minimal. PMID:19047482
21. membrane cholesterol content is a critical determinant of ABCB11/ABCC2 transport activity, which might provide an explanation for the etiology of ATP8B1 disease PMID:19228692
22. Report Role of hepatic Bsep transporter in prevention of bile acid toxicity after partial hepatectomy in mice. PMID:19497955
23. triple knockout mouse (Mdr1a & Mdr1b &BSEP) is the most severe genetic model of intrahepatic cholestasis yet developed. P-glycoprotein functions as a critical compensatory mechanism, which reduces the severity of cholestasis in Bsep knockout mice. PMID:19650158

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UNIGENE: Mm.439855

KEGG: mmu:27413

STRING: 10090.ENSMUSP00000099770