Recombinant Mouse Bcl-2-associated transcription factor 1 (Bclaf1), partial

Product Details

Abbreviation
Bclaf1
Purity
>85% (SDS-PAGE)
Target Names
Bclaf1
Uniprot NO.
Alternative Names
Bclaf1; Btf; Kiaa0164Bcl-2-associated transcription factor 1; Btf
Species
Mus musculus (Mouse)
Source
Yeast
Expression Region
1-919
Target Protein Sequence
MGRSNSRSHS SRSKSRSQSS SRSRSRSHSR KKRYSSRSRS RTYSRSRSRD RIYSRDYRRD YRNNRGMRRP YGYRGRGRGY YQGGGGRYHR GGYRPVWNRR HSRSPRRGRS RSRSPKRRSV SSQRSRSRSR RSYRSSRSPR SSSSRSSSPY SKSPVSKRRG SQEKQTKKAE GEPQEESPLK SKSQEEPKDT FEHDPSESID EFNKSATSGD IWPGLSAYDN SPRSPHSPSP IATPPSQSSS CSDAPMLSTV HSAKNTPSQH SHSIQHSPER SGSGSVGNGS SRYSPSQNSP IHHIPSRRSP AKTITPQNAP REESRGRSSF YPEGDQETAK TGKFLKRFTD EESRVFLLDR GNIRDKEAPK EKGSEKGRAD GDWDDQEVLD YFSDKESAKQ KFHDSEGDDT EETEDYRQFR KSVLADQGKS FATSSHRNTE EEGPKYKSKV SLKGNRESDG FREEKNYKLK ETAYIVERPS TAKDKHKEED KGSDRITVKK EVQSPEQVKS EKLKELFDYS PPLHKSLDAR EKSIFREESP LRIKMIASDS HRPEVKLKMA PVPLDDSNRP ASLTKDRLLA STLVHSVKKE QEFRSIFDHI KLPQANKSTS ESFIQHIVSL VHHVKEQYFK SPAVTLNERF TSYQKATEEH STRQKSPEIH RRIDISPSAL RKHTRLAGEE RGFKEEIQKG DKKLRCDSAD LRHDIDRRRK ERSKERGDSK GSRESSGSRK QEKTPKDYKE YKPYKDDSKH KGRERDHSRS SSSSASPSSP SSREEKESKK EREEEFKTHH EMKDYSGFAG VSRPRGTFFR IRGRGRARGV FAGTNTGPNN SNTTFQKRPK EEEWDPEYTP KSKKYFLHDD RDDGVDYWAK RGRGRGTFQR GRGRFNFKKS GSSPKWTHDK YQGDGIVEDD EETMENNEEK KDRRKEEKE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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 Customer Reviews

Target Background

Function(From Uniprot)
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Gene References into Functions
  1. Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation. PMID:28120329
  2. Bclaf1 facilitates the differentiation of early retinal precursors into retinal ganglion cells, amacrine cells, and horizontal cells rather than into cone photoreceptors. PMID:24453340
  3. Sirt1 negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1 PMID:21454709
  4. Bclaf1 expression was found to be strongly upregulated during the saccular stage of murine embryonic lung development and was dispensable for thymocyte development. PMID:19008920

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Subcellular Location
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
Protein Families
BCLAF1/THRAP3 family
Database Links
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No. 269, Shendun 5th Road, Donghu Hi-Tech Development Area, Hubei Province, 430206, P.R.China
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