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Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1)

Recombinant Mouse BAG family molecular chaperone regulator 1 (Bag1)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Bag1

Purity

>85% (SDS-PAGE)

Target Names

Bag1

Uniprot NO.

Q60739

Alternative Names

Bag1BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-355

Target Protein Sequence

MAGRSAARRP RGDREPLGPR LRAPRPAREP RQSESRAERG LPPSQRSSVR SAASGHDRST RGAPAGACKP RVKKKVRPRS SQSEKVGSSS RELTRSKKVT RSKNVTGTQV EEVTKIEEAT QTEEVTVAEE VTQTDNMAKT EEMVQTEEME TPRLSVIVTH SNERYDLLVT PQQGNSEPVV QDLAQLVEEA TGVPLPFQKL IFKGKSLKEM ETPLSALGMQ NGCRVMLIGE KSNPEEEVEL KKLKDLEVSA EKIANHLQEL NKELSGIQQG FLAKELQAEA LCKLDRKVKA TIEQFMKILE EIDTMVLPEQ FKDSRLKRKN LVKKVQVFLA ECDTVEQYIC QETERLQSTN LALAE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Gene References into Functions

These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation. PMID:28502705
that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways PMID:28523530
These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions. PMID:27633857
The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation. PMID:23178238
The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high. PMID:24628338
Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment PMID:23521418
this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein. PMID:23277101
Bag-1 proteins function as regulators of the action of selective transcription factors. PMID:20858459
during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1) PMID:11804787
Bag1 is a regulator and marker of neuronal differentiation PMID:11965493
BAG1 displays potent neuroprotective activity in vivo against stroke. PMID:14655755
Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death. PMID:15781153
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells. PMID:16116448
Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover PMID:17950682
BAG-1 associates with Tau protein in an Hsc70-dependent manner. PMID:17954934
BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments PMID:18562287
These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain. PMID:19084526
The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon. PMID:9396724
Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons. PMID:9679980

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Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.

Tissue Specificity

Isoform 2 is expressed in the heart, lung, kidney and spinal cord. Isoform 1 and isoform 2 are expressed in hematopoietic cell lines. The levels of isoform 2 are relatively constant in all the cell lines examined while the levels of isoform 1 are more var

Database Links

UNIGENE: Mm.688

KEGG: mmu:12017

STRING: 10090.ENSMUSP00000030125

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