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Recombinant Mouse B-cell lymphoma/leukemia 11A (Bcl11a)

Recombinant Mouse B-cell lymphoma/leukemia 11A (Bcl11a)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Bcl11a

Purity

>85% (SDS-PAGE)

Target Names

Bcl11a

Uniprot NO.

Q9QYE3

Alternative Names

Bcl11a; Ctip1; Evi9; Kiaa1809B-cell lymphoma/leukemia 11A; BCL-11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein; EVI-9

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-773

Target Protein Sequence

MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ CQMNFPLGDI LIFIEHKRKQ CNGSLCLEKG VDKPPSPSPI EMKKASNPVE VGIQVTPEDD DCLSTSSRGI CPKQEHIADK LLHWRGLSSP RSAHGALIPT PGMSAEYAPQ GICKDEPSSY TCTTCKQPFT SAWFLLQHAQ NTHGLRIYLE SEHGSPLTPR VGIPSGLGAE CPSQPPLHGI HIADNNPFNL LRIPGSVSRE ASGLAEGRFP PTPPLFSPPP RHHLDPHRIE RLGAEEMALA THHPSAFDRV LRLNPMAMEP PAMDFSRRLR ELAGNTSSPP LSPGRPSPMQ RLLQPFQPGS KPPFLATPPL PPLQSAPPPS QPPVKSKSCE FCGKTFKFQS NLVVHRRSHT GEKPYKCNLC DHACTQASKL KRHMKTHMHK SSPMTVKSDD GLSTASSPEP GTSDLVGSAS SALKSVVAKF KSENDPNLIP ENGDEEEEED DEEEEEEEEE EEEELTESER VDYGFGLSLE AARHHENSSR GAVVGVGDEG RALPDVMQGM VLSSMQHFSE AFHQVLGEKH KRSHLAEAEG HRDTCDEDSV AGESDRIDDG TVNGRGCSPG ESASGGLSKK LLLGSPSSLS PFSKRIKLEK EFDLPPAAMP NTENVYSQWL AGYAASRQLK DPFLTFGDSR QSPFASSSEH SSENGSLRFS TPPGELDGGI SGRSGTGSGG STPHISGPGP GRPSSKEGRR SDTCPSHTPV RRSTPRAQDV WQFSDGSSRT LKF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes. May play a role in hematopoiesis. Essential factor in lymphopoiesis, required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.

Gene References into Functions

Our studies define a mechanism for BCL11A in regulation of hematopoietic stem cell function PMID:27653684
Bcl11a enhancer-deleted mice, Bcl11a(Deltaenh), phenocopy the BCL11A-null state with respect to alterations of globin expression. PMID:27707736
data identify Ctip1 as a critical control over sensory cortex development PMID:27100196
Bcl11a haploinsufficiency in mice causes impaired cognition, abnormal social behavior, and microcephaly in accordance with the human phenotype PMID:27453576
deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice PMID:26390863
This study showed that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription PMID:26182416
The results of this study support a role for CTIP1 on the specification of the Subcerebral Projection Neurons in layer 5 through the repression of TBR1 and the promotion of CTIP2 expression. PMID:25972180
BCL11A is an essential, lineage-specific factor that regulates plasmacytoid dendritic cell development, supporting a model wherein differentiation into pDCs represents a primed "default" pathway for common dendritic cell progenitors. PMID:24591644
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PMID:23741395
BCL11A contains F/YSXXLXXL/Y motifs that mediate highly selective binding to the LBDs of orphan nuclear receptors NR2E1/TLX, NR2E3/PNR and the NR2F/COUP-TF family. These motifs are required for BCL11A/COUP-TFII-mediated repression of foetal globin genes and a lncRNA termed Bgl3. The motifs are conserved in other nuclear receptor cofactors such as NSD1, constituting a new signature motif related to LXXLL and the CoRNR box. PMID:23975195
Immunohistochemical staining of mouse brain showed strong expression of BCL11A in the cortical regions and also in the pyramidal cell layers in the CA1 and CA3 regions of the hippocampus. PMID:23975195
data support an important role for the KLF1-BCL11A axis in erythroid maturation and developmental regulation of globin expression PMID:23361909
Overexpression of Bcl2 and Mdm2, or p53 deficiency, rescues both lethality and proliferative defects in Bcl11a-deficient early B cells. PMID:23230003
BCL11A is required for silencing of gamma-globin expression in adult animals yet dispensable for red cell production; inactivation of BCL11A in sickle cell disease (SCD) transgenic mice corrects defects associated with SCD through HbF induction PMID:21998251
Bcl11a is essential for postnatal development and normal lymphopoiesis. PMID:12717432
CTIP1 and CTIP2 have roles in the development and function of both the central nervous and immune systems PMID:15465497
Bcl11a is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. PMID:18681895
deregulated Bcl11a cooperates with Nf1 in leukemogenesis PMID:18948576
BCL11A is a critical mediator of species-divergent globin switching PMID:19657335

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Subcellular Location

Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.

Tissue Specificity

Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpressi

Database Links

UNIGENE: Mm.53687

KEGG: mmu:14025

STRING: 10090.ENSMUSP00000105140

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