Recombinant Mouse Axin-2 (Axin2), partial

1. Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury. PMID:27853243
2. identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling. PMID:28520221
3. increased mesenchymal Wnt signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 antagonistic interactions modulate the level of mesenchymal Wnt/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 mutations PMID:29437780
4. we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM) containing knockout serum replacement (KSR) exhibited higher levels of expression of axin2, a Wnt target gene, than those grown in chemically defined medium PMID:27151576
5. Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals. PMID:27144473
6. Axin2 limits Wnt/beta-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/beta-catenin signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease. PMID:28069701
7. Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers PMID:27578179
8. Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt/beta-catenin pathway. PMID:27701636
9. The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis PMID:26929341
10. Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling. PMID:26903625
11. Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation. PMID:26220362
12. These data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation. PMID:24973690
13. implants lacking primary stability undergo osseointegration, provided Wnt signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement. PMID:24164629
14. Axin2(-/-) PF-sutures lack physiological endochondral ossification PMID:23936395
15. Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone. PMID:23589866
16. Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea. PMID:23444352
17. Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice PMID:23300083
18. Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos. PMID:22479388
19. Lgr5 and Axin2 differential expression among cell populations highlights the dynamic but complex distribution of Wnt-activated cells in and around the embryonic and postnatal cochlea. PMID:21472479
20. although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues, stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak. PMID:21555575
21. Results suggest a key regulatory pathway of Axin2/beta-catenin/cyclin D1 in development of the suture mesenchyme. PMID:21108844
22. Data show that knockout of gene Axin2, a negative regulator of the WNT-beta-catenin pathway, and gene FGFR1 induced ectopic chondrogenesis, leading to abnormal suture morphogenesis and fusion. PMID:20501936
23. Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre- and postnatal tooth development. PMID:19653310
24. Disruption of Axin2 induces malformations of skull structures resembling craniosynostosis in humans; these are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis. PMID:15790973
25. Axin 2 was shown to be functionally equivalent to axin. PMID:15899843
26. The oscillation of Dact1 occurs in phase with the Wnt signaling component Axin2, and out of phase with the Notch signaling component Lfng. PMID:17013874
27. Axin2 negatively regulates both expansion of osteoprogenitors and maturation of osteoblasts through its modulation on Wnt/beta-catenin signaling PMID:17113065
28. Axin2 expressing cells that co-express Sca-1 are present in all prostate lobes suggesting that progenitor cells reside within the Wnt active population. PMID:18563716
29. Axin2 is a negative regulator in bone remodeling in adult mice and regulates psteoblast differentiation through the beta-catenin-BMP2/4 signaling pathway in osteoblasts. PMID:19737815

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UNIGENE: Mm.71710

KEGG: mmu:12006

STRING: 10090.ENSMUSP00000051331