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Recombinant Mouse Autophagy-related protein 13 (Atg13)

Recombinant Mouse Autophagy-related protein 13 (Atg13)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Atg13

Purity

>85% (SDS-PAGE)

Target Names

Atg13

Uniprot NO.

Q91YI1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-516

Target Protein Sequence

METELSSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW FNLAIKDIPE VTHEAKKALS GQLPAVGRSM CVEISLKTSE GDSMELEIWC LEMNEKCDKE IKVSYTVYNR LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI LYRIYFGEVQ LNGLGEGFQT VRVGTVGTPV GTLTLSCAYR INLAFMSTRQ FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAEDAGVA YPSVEDSQEV CTTSFSTSPP SQLSSSRLSY QPAVLGLGSA DLAYPVVFTA GLNTTHAHQL MVPGKEGGVT LAPSHPTHGA QADPERLVMH MPSDGTHCAA TPSSSEDTET VSNSSEGRAS PHDILETIFV RKVGAFVNKP INQVTVTSLD IPFAMFAPKN LELEDADPMV NPPESPETTS PLHGSLHSDG SSGGSGGSTH DDFVMIDFKP AFSKDDILPM DLGTFYREFQ NPPQLSSLSI DFGAQSMAED LDSLPEKLAV HEKNVREFDA FVETLQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Gene References into Functions

ATG13 phosphorylation plays a crucial role in autophagy regulation. PMID:26801615
Atg13-deficient embryos show growth retardation and myocardial growth defects. PMID:26644405

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Subcellular Location

Cytoplasm, cytosol. Preautophagosomal structure.

Protein Families

ATG13 family, Metazoan subfamily

Database Links

UNIGENE: Mm.28492

KEGG: mmu:51897

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