Recombinant Mouse Arylsulfatase A (Arsa)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Arsa

Uniprot NO.

P50428

Alternative Names

Arsa; As2; Arylsulfatase A; ASA; EC 3.1.6.8; Cerebroside-sulfatase

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

18-506

Target Protein Sequence

SPP NILLIFADDL GYGDLGSYGH PSSTTPNLDQ LAEGGLRFTD FYVPVSLCTP SRAALLTGRL PVRSGMYPGV LGPSSQGGLP LEEVTLAEVL AARGYLTGMA GKWHLGVGPE GAFLPPHQGF HRFLGIPYSH DQGPCQNLTC FPPDIPCKGG CDQGLVPIPL LANLTVEAQP PWLPGLEARY VSFSRDLMAD AQRQGRPFFL YYASHHTHYP QFSGQSFTKR SGRGPFGDSL MELDGAVGAL MTTVGDLGLL EETLVIFTAD NGPELMRMSN GGCSGLLRCG KGTTFEGGVR EPALVYWPGH ITPGVTHELA SSLDLLPTLA ALTGAPLPNV TLDGVDISPL LLGTGKSPRK SVFFYPPYPD EIHGVFAVRN GKYKAHFFTQ GSAHSDTTSD PACHAANRLT AHEPPLLYDL SQDPGENYNV LESIEGVSPE ALQALKHIQL LKAQYDAAMT FGPSQIAKGE DPALQICCQP SCTPHPVCCH CPGSQS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Hydrolyzes cerebroside sulfate.

Gene References into Functions

Multipotential Neural precursors deficient in arylsulfatase A show a higher ratio of long versus short fatty acid sulfatides, reduction in PDGFRa, decreased AKT phosphorylation, and increased exosomal shedding of PDGFRa. PMID:25605750
distributed not only on the cell surfaces of endothelial cells and hepatocytes, but also on the collagen fibrils in the space of Disse PMID:23883774
Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner. PMID:22685254
Sulfogalactosylglycerolipid was a physiological substrate of Sertoli lysosomal arylsulfatase A PMID:21965315
study provides the first proof of cognitive deficit and impaired synaptic plasticity in an MLD mouse model. PMID:21459117
ArsA plays a role as a novel component of the extracellular matrix which could be very useful for clarifying the mechanisms underlying some of the syndromes caused by functional deficiency of the Ars genes. PMID:20297902
Data demonstrate a delay in myelin formation in ASA-deficient mice at 2 weeks of age, as a consequence of inability to degrade sulfatide. PMID:15733089
Since high cholesterol levels are important for myelination, and various cellular processes, like vesicular trafficking and signal transduction, reduced cholesterol levels might be an important factor in the molecular pathology of MLD. PMID:16630546
ASA-deficient [ASA(-/-)] mice overexpressing the sulfatide synthesizing enzymes causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy PMID:17715338
The increasing sulfatide storage in ASA(-/-) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD. PMID:17728461
Safety of Arsa overexpression for gene therapy of metachromatic leukodystrophy was evaluated. PMID:17845130
Lysosomal AS-A may be involved in cell-surface remodeling during luteolysis by desulfating SGG after its endocytosis and targeting to the lysosome. PMID:18420734
Saposin B(Sap B) is not a limiting factor of the coupled Sap B-ASA reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels PMID:19224915