Recombinant Mouse Antithrombin-III (Serpinc1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Serpinc1

Uniprot NO.

P32261

Alternative Names

Serpinc1; At3Antithrombin-III; ATIII; Serpin C1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

33-465

Target Protein Sequence

HGNPVDDI CIAKPRDIPV NPLCIYRSPG KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA DSKNDNDNIF LSPLSISTAF AMTKLGACND TLKQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SDLVSANRLF GDKSLTFNES YQDVSEVVYG AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI NELTALVLVN TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV VHMPRFRTED GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA FHKAFLEVNE EGSEAAASTS VVITGRSLNP NRVTFKANRP FLVLIREVAL NTIIFMGRVA NPCVN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Gene References into Functions

RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis. PMID:23550037
Mice homozygous for the heparin-binding domain mutation R48C developed spontaneous, life-threatening thrombosis, occurring as early as the day of birth. Only 60% of the offspring reached weaning age, with further loss at different ages PMID:14592998
in the heart, TF plays an important role in the thrombogenesis and it counterbalances AT-dependent anticoagulation; regulation of TF-procoagulant activity take place differently between the liver and the heart PMID:16409467

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Subcellular Location

Secreted, extracellular space.

Protein Families

Serpin family

Tissue Specificity

Plasma.

Database Links

UNIGENE: Mm.260770

KEGG: mmu:11905

STRING: 10090.ENSMUSP00000068971

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