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Recombinant Mouse Alstrom syndrome protein 1 homolog (Alms1), partial

Recombinant Mouse Alstrom syndrome protein 1 homolog (Alms1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Alms1

Purity

>85% (SDS-PAGE)

Target Names

Alms1

Uniprot NO.

Q8K4E0

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-3251

Target Protein Sequence

MEPEDLPWPD ELEEEEEEEE EEGEEEEGKK EVENASAAAT EEALTSEESG RLEEFEEAGP DLDFNYESQR QESSDEEEDE LAKAWLQAHP DRPGSAFSLP PPTPPPPPPP LSPRLRYTPV EHLGKTEVVP LTCRVWQQSS YQDNSRAQFS NSSTMLLETG VRWGSEEDQR TESWHCLPQE RDSSQTLAMS QTEIGRVEGT EVPDLPSQEG GLPAQSQCPG KKPKLNVLCS PLLVIQDNFA APDLPLLTCL IQDQEEVEPD SLFQQSELEF APLRGIPDKS EDSEWLARPS EVSEALIQAT SETSSDLANS CFSISQHPLT EGLQGKAESG VLTRCGDAKY SSLYENLGAQ SERIAVLQRE VGCSNLGISQ ASPSSLPSFV PQEPTSEPEY HSSNLRMLRV SPDTLLTTHT HSAGSADQKI GAAVVSSAYS QEIKPGSFHQ EELPDRHLNE EIRKVSPALR TAGQKPEMLP VQSSSYSKGM KSIFYQHPVS HGHQGKEPLS VSAVCGSAGN KAFHQLSTLS DSLLTEETWP VSVIPGLGNQ KTPLPSEFSL SYSHRGKNLP EDVVKVSTDS GSAHKKADIL TASSRTYQHK MKPANIYHQE LPDSRVPIGT RKVAFESGPA GQKSGVSHPY GEMPSVFYQQ GLPDRHSAKS PTKTFIPGPA DQKTDLSPVP PTSSSHAEKP VSPYQLTLPG SHLPEDVFKA SSVCKSSDEL SGITALTSAS YSYKGRPNSS YQQKFPDSHL NEEAQKILGT TGTVDQKTVT PTMSSSFLQK EKPSIFYQQT LPDGGLSEED LQVSAVPWPA DQNIAIPTVT SAAFSQREKP RIFYQQTLSV DRLPGEPLNV LGTSGPPDQN TGAPTVTPSS YFPGEESIIF YQAGFPGNTL SAMSFKVPRI SGSTEQTNVT TGSSSSYSVG EKSIIFYHQA LPDGRLPQEA SPAPADLNTG EPPMYLASCS VGVKPIIFYQ QPMSDSQRTK GHKESDVPGP TDQKTGIATV HSTSQSYIGR RTVSYQKEFP DLSEKALKVL GDVGSTEQKT QIPVVSSALL HKEGPSAYQE DLPDLTEEPL QILGVSEEVS SSSYQRKLPD HIEVFLKSVG SGSADRKTGA QIVSSSREKS SGFHQQELPN TGGDAVDAFH PEPVVQEVRK VQTPGAPAGP SSSHFHKEKL SDYQKASPHR DLTESSLKAS TVPGLSDQKK KPAVSSGFCL HKEKHEISAS ALLNCQTAEL LTVTQRSCLH REDPAISTVI KPDDQKIPLP TTFHGSSDQK VKPVIFVQKQ LRDRDQSEDI PKISTVSEPT VVNTVLPVLL PGSYSHREKS DSFYPQELPD GHLTEVDLKV SSGLGQADQI SGLPTGIPGT YSHSEKHQLI SEHVQELMDN LNSSESSCLS VDSMPLNSQI DDGVIICKPE SLGFANAGCE EMQNIDRGSK TLKEIQTLLM EAENMALKRC NFSVPLVPFR DVNDVSFIRS KKVVCFKESS TTDVCTQRES FVEEVPHIEY VQKDIGTQTN LKYQRGVGNW EFISSATFRS PLQEAEGTAR MAYDETFRQY KAARSVMRSE PEGCSTGIGN KMIIPMMTII KSDSSSDVSD GCCSWDNNLP ESLESVSDVF LNFFPYTSPK TSITDSREEE WLSESEDGYG STDSLAAHVK YLLQCETSLN QAKQILKNAE EEEYRVRTQA WNLKFNLGRD RGYSISELNE DDRRKVEEIK AKLFGHGRAT HMSEGLRSPQ GIGCLPEAVC SRIIIESHEK GCFRTLTAEQ PRPDSCHCAF RSVEPSDLIR GHRSPSSWRG RHINLSRSIE QSNPCFKVGS SFQLQSHPPF QKLLPDDIKI SKGVGMPVHA YMDPQPSELV EPTCVPAKEM DFPSSSQILP PEPKKQFTTA ITFSSHEHSE CISDSSGCKV GVTADSQCSG PSLGVFKPHI PEEQISPRDL KQKTSFQSSL ERHGSTPVTI LADGSRQRQK LPVDFEHSHQ KEKLLQRLGF KVSHSEPNVS TNVSNFKGVQ FSGKDTIVSQ DKLTSTVEVK EKNVTVTPDL PSCIFLEQPE LFEESHTPHT DLQMRKYPSP SCPEIASRIF LEQPKLSEQS KAPHVDREIR EDHSFFPKCQ DYIVADPSPD FPDQQQCKPP DVVGHTRKQN SLLSEGQDYE LEEVQHIPQS YFSNMVNVEA KVSDAISQSA PDHCTAASTP PSNRKALSCV RITLCPKTSS KLDSGTLGER FHSLDPASKT RINSEFNSDL RIISSRSLEP TSKLLTCKPV AQDQESLVFL GPKSPLDLQV AQSSLPDSKT IFQDLKTKPP QNSQIVTSRQ TQVNISHLEG YSKPEGTPVS ADGSQEQSKV SFTTSFGKLS SDAITQITTE SPEKTTFSSE IFIHADDRGQ GILDPMAQKP SRFASSSSVQ QIPASHGKDA QPVLLPYKPS GSSKMYYVPL LKRVPSYLDS KSDTTVESSH SGSNDAIAPD FPPQMLGTRD DDLSNTVNIK HKEGIYSKRA ATKGKNPSQK GDAAAPVQMP ITWDENVLDE NQEEVISRGV VIKMAGPEEM SSLEKDLAGP SDITVQDRKT ENLPDTKSIK QKEGSLEIES ECHSAFENTA HSVFRSAKFY FHHPVHLPHE QDFCHESLGR SVFMQHSWKD FFHHHSGHSC LPPPGPSSDK LDKTKMDYTR IKSLSINLNL GEHEKIHTIK NQARDPKGKR QANEQKKDQK VTPELTTECP VSLNELWNRY QERQKQQNPS GACDTKELSL VERLDRLAKL LQNPITHSLR ASESAQDDSR GGHRAREWTG RRQQKQKGKQ HRKWSKSLER GQSTGDFRKS KVFSPHQGGK SSQFKIEQIK LDKYILRKEP GFNNVSNTSL DSRPSEESVS LTDSPNIFSS TDSPVDSDVL TPTDRDMPLN ERSSSISTID TVRLIQAFGQ DRLSLSPRRI KLYSTVTSQR RRYLEQPCKH NRKALNTACP QMTSEHSRRR HIQVANHMTS SDSVSSPGSL LSLDSALSNE ETVRMVSKGV QAGNLEIVAG VKKYTQDVGV TFPTPSSSEA RLEEDSDVTS SSEEKAKEKK FLSNYLQTKN LRKNKPNPCA GVSWFVPVES GQSGSKKENL PKIYRPVISW FEPVTKTKPW REPLREQNWQ AQCMNSRGSL GGPGRDSGQV SLRPFVRATL QESLQLHRPD FISHSGERIK RLKLLVQERK LQSLFQSERE ALFHSARPLP RRVLLAVQKN KPIGKKEMIQ RTRRIYEQLP EVKKKREEEK RKSEYKSYWL RAQHYKMKVT NHLLGRKVPW D
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells.

Gene References into Functions

GLUT4 defects in adipose tissue are early signs of metabolic alterations in Alms1-deficient mice, a mouse model for obesity and insulin resistance. PMID:25299671
Data conclude that deficiency of Alstrom protein impairs postnatal cardiomyocyte cell cycle arrest. PMID:24595103
This study demonitrated that Alms1 localizes at the base of cilia in hypothalamic neurons and Alms1 is lost from this location in foz/foz mice. PMID:22581473
a role for ALMS1 variants in the recycling endosome pathway PMID:22693585
investigated the role of ALMS1 in the cochlea and the pathogenesis of hearing loss in Alstrom Syndrome PMID:21071598
Disruption in ALMS1 manifests human Alstrom syndrome PMID:16000322
In this model of metabolic syndrome, transition of steatosis to steatohepatitis was associated with hypoadiponectinemia, a mediator of hepatic fatty acid disposal pathways. PMID:16516152
In vitro knockdown of Alms1 in mice causes stunted cilia on kidney epithelial cells and prevents these cells from increasing calcium influx in response to mechanical stimuli. PMID:17206865

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole.

Tissue Specificity

Ubiquitously expressed.

Database Links

UNIGENE: Mm.246967

KEGG: mmu:236266

STRING: 10090.ENSMUSP00000071904

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