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Recombinant Mouse Alpha-2-macroglobulin-P (A2mp), partial

Recombinant Mouse Alpha-2-macroglobulin-P (A2mp), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

A2mp

Purity

>85% (SDS-PAGE)

Target Names

A2m

Uniprot NO.

Q6GQT1

Alternative Names

A2m; A2mpAlpha-2-macroglobulin-P; Alpha-2-macroglobulin

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

33-1474

Target Protein Sequence

PQKPIYMV MVPSLLHAGT PEKGCLLFNH LNETVTVKVS MESVRGNQSL FTDLVVDKDL FHCASFIVPQ SSSNEVMFLT VQVKGPTHEF RRRSTVLIKT KESLVFAQTD KPIYKPGQMV RFRVVSLDEN FHPLNELIPL LYIQDSKKNR IAQWQNFRLE GGLKQLSFPL SSEPTQGSYK VVIRTESGRT VEHPFSVKEF VLPKFEVKVA VPETITILEE EMNVSVCGIY TYGKPVPGHV TVNICRKYSN PSSCFGEESL AFCEKFSQQL DGRGCFSQLV KTKSFQLKRQ EYEMQLDVNA KIQEEGTGVE ETGKGLTKIT RTITKLSFVN VDTHFRQGIP FVGQVLLVDG RGTPIPYEMI FIGADEANQN INTTTDKNGL ARFSINTDDI MGTSLTVRAK YKDSNVCYGF RWLTEENVEA WHTANAVFSP SRSFVHLESL PYKLRCEQTL AVQAHYILND EAVLERKELV FYYLMMAKGG IVRAGTHVLP VTQGHKKGHF SILISMETDL APVARLVLYT ILPNGEVVGD TVKYEIEKCL ANKVDLVFHP NIGLPATRAF LSVMASPQSL CGLRAVDQSV LLTKPEAELS ASLVYDLLPV KDLTGFPKGV NQQEEDTNGC LKQNDTYING ILYSPVQNTN EEDMYGFLKD MGLKVFTNLN IRKPKVCERL GVNKIPAAYH LVSQGHMDAF LESSESPTET TRSYFPETWI WDLVIVDSTG VAEMEVTVPD TITEWKAGAF CLSNDTGLGL SPVIDFQAFQ PFFVDLTMPY SVIRGEAFTL KATVLNYLQT CIRVGVQLEA SPDFLATPEE KEQKSHCICM NERHTMSWAV IPKSLGNVNF TVSAEALDSK ELCRNEVPVV PERGKKDTII KSLLVEPEGL ENEVTFNSLL CPTGAEVSEQ ISLKLPSDVV EESARASVTV LGDILGSAMQ NTQDLLKMPY GCGEQNMVLF APNIYVLDYL NETEQLTQEI KTKAITYLNT GYQRQLNYKH RDGSYSTFGD KPGRSHANTW LTAFVLKSFA QARRYIFIDE SHITQALTWL SQQQKDNGCF RSSGSLLNNA MKGGVEDEVT LSAYITIALL EMSLPVTHPV VRNALFCLDT AWKSARRGAS GNHVYTKALL AYAFALAGNQ DTKKEILKSL DEEAVKEDNS VHWTRAQKPR VPADLWYQPQ APSAEVEMTA YVLLAYLTTE LVPTREDLTA AMLIVKWLTK QQNSHGGFSS TQDTVVALHA LSKYGAATFT RAKKAAHVTI QSSGAFYTKF QVNNDNQLLL QRVTLPTVPG DYTAKVAGEG CVYLQTSLKY SVLPREKEFP FALVVQTLPG TCEDLKAHTT FQISLNISYI GSRSDSNMAI ADVKMVSGFI PLKPTVKMLE RSVHVSRTEV SNNHVLIYLD KVSNQMLTLF FMVQQDIPVR DLKPAIVKVY DYYEKDEFAV AKYSAPCSAG YGNA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene References into Functions

To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice PMID:27031383
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase. PMID:21320498
MMP9 production promoted by the alpha(2)M*/LRP1 interaction required the activation of both MAPK-ERK1/2 and NF-kappaB signaling pathways. PMID:20568116
Alpha2 macroglobulin requires cyclic amp and signal transduction for cell growth PMID:12114513
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. PMID:12183561
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents PMID:15355875
Data describe the role of the PI3-kinase/PDK/Akt/p70s6k signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB in these events. PMID:15389876
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy. PMID:16297527
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind PMID:16407218
PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit PMID:16641085
IL-11 signals through the Jak2/Stat3 pathway in decidual cells to stimulate the expression of alpha(2)-MG, a protease inhibitor essential for normal placentation in pregnancy. PMID:16959875
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin PMID:19536284

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Subcellular Location

Secreted.

Protein Families

Protease inhibitor I39 (alpha-2-macroglobulin) family

Tissue Specificity

Expressed in uterus, mesometrial lymphoid aggregate and mammary tissue during pregnancy. Expressed in ovary, testis and kidney. Low level expression in heart. Not expressed in liver.

Database Links

UNIGENE: Mm.30151

KEGG: mmu:232345

STRING: 10090.ENSMUSP00000032203

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