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Recombinant Mouse Activin receptor type-1C (Acvr1c), partial

Recombinant Mouse Activin receptor type-1C (Acvr1c), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Acvr1c

Purity

>85% (SDS-PAGE)

Target Names

Acvr1c

Uniprot NO.

Q8K348

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Gene References into Functions

Data, including data from studies using knockout mice, suggest that Gdf3-Alk7 axis between adipose tissue macrophages and adipocytes represents previously unrecognized mechanism by which insulin regulates both fat metabolism/lipolysis and adiposity. (Gdf3 = growth differentiation factor-3; Alk7 = activin receptor-like kinase-7) PMID:29945891
Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax. PMID:28927503
ALK7 protects against pathological cardiac hypertrophy in mice. PMID:26249805
These findings suggest that endogenous expression of ALK7 is necessary to maintain repolarizing K+ currents in ventricular cardiomyocytes, and finally prevent action potential prolongation and ventricular arrhythmia. PMID:26882027
ALK7 signaling contributes to diet-induced catecholamine resistance in adipose tissue; ALK7 inhibitors may have therapeutic value in human obesity. PMID:25161195
Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PMID:23342175
Alk7 is involved in modulation of adipose tissue metabolism in response to beta3-adrenergic receptor activation. PMID:23264230
Data indicate that activin receptor ALK7-knockout females showed delayed onset of puberty and abnormal estrous cyclicity. PMID:22954591
Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor gamma and C/EBPalpha. PMID:22933117
Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity PMID:22056140
ALK7 is the signaling receptor for activin AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID:15196700
ALK7 is not an essential mediator of Nodal signaling during mesendoderm formation and left-right patterning in the mouse but may instead mediate other activities of Nodal and related ligands in the development or function of particular tissues and organs PMID:15485907
These results indicated that ALK7 is a novel marker specifically expressed during the late phase of adipocyte differentiation. PMID:16953060
ALK7 plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca(2+) signaling PMID:18480258
GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID:18480259