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Recombinant Mouse ATP-binding cassette sub-family A member 7 (Abca7), partial

Recombinant Mouse ATP-binding cassette sub-family A member 7 (Abca7), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Abca7

Purity

>85% (SDS-PAGE)

Target Names

Abca7

Uniprot NO.

Q91V24

Alternative Names

Abca7ATP-binding cassette sub-family A member 7

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing.

Gene References into Functions

Study demonstrates that changes in surface CD1d expression and intracellular trafficking, as well as reduced CD1d localization to lipid rafts, are all caused by the absence of the ATP binding cassette transporter ABCA7. PMID:28091533
ABCA7 does not play a significant role in the regulation of cell proliferation or neurogenesis in the adult mouse. PMID:26792809
This study demonstrated that novel mechanism underlying how dysfunctions of ABCA7 contribute to the risk for alzheimer disease. PMID:27030769
ABCA7 has a role in Alzheimer amyloid processing PMID:26260791
Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta homeostasis in the brain and that this may be related to altered phagocyte function. PMID:23467355
Male knockout mice exhibited significantly impaired novel object recognition memory.Female knockout mice exhibited impaired spatial reference memory. PMID:23029339
ABCA7 may play a role in T cell proliferation and erythropoeisis in spleen PMID:22403608
concluded that statins enhance macrophage phagocytosis through the SREBP-ABCA7 pathway. PMID:21762915
Data suggest that extracellular helical apolipoproteins augment ABCA7-associated phagocytosis by stabilizing ABCA7, and show direct enhancement of the host defense system by HDL components. PMID:20495215
ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and has a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues PMID:12917409
genetic knockdown of ABCA7 in mouse peritoneal macrophages did not affect phospholipid or cholesterol efflux to apoA-I PMID:15520449
ABCA7 plays a novel role in lipid and fat metabolism PMID:15550377
Mouse spermatozoa in the seminiferous tubules and epididymis express ABCA1, ABCA7 and ABCG1. PMID:18793613

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, ruffle membrane. Cell projection, phagocytic cup.

Protein Families

ABC transporter superfamily, ABCA family

Tissue Specificity

Widely expressed with higher expression in brain, lung, adrenal gland, spleen and hematopoietic tissues (at protein level). In the brain, expressed in cortex, cerebellum, hippocampus, olfactory bulb, neurons, astrocytes and microglia (at protein level). A

Database Links

UNIGENE: Mm.103351

KEGG: mmu:27403

STRING: 10090.ENSMUSP00000043090

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