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Recombinant Mouse A-kinase anchor protein 9 (Akap9), partial

Recombinant Mouse A-kinase anchor protein 9 (Akap9), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Akap9

Purity

>85% (SDS-PAGE)

Target Names

Akap9

Uniprot NO.

Q70FJ1

Alternative Names

Akap9; Kiaa0803A-kinase anchor protein 9; AKAP-9; Protein kinase A-anchoring protein 9; PRKA9

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-3797

Target Protein Sequence

MEDEERQRKL AAGKAKLARF RQRKAQYDGD IPKKQKKKRT SSSKHDSSLH TDQQSGELCS ESSQRVDLAG NPDCSGPERK HGQVFSAEPE SEISTTADEC SSEINGCNSV MKPRKPTDPL REEEFSLDDS SSEQGAQSSQ TCLQMVEKEL AEKQHDIEEL TQELEEMRAS FGTEGLKQLQ EFEAAIKQRD GIITQLTANL QQARREKDDT MVEFLELTEQ SQKLQIQFQH LQANETLQNS TLSRTATDLL QAKRQIFTQQ QQLQDYQKKE EDLQAQISFL QEKLRAFEME KDRKIENLNA KEIQEKQALI DELNTRVVEE EKKTVELKNK VTTADELLGG LHEQLTQRNQ EIQSLKLELG NSQQNERKCS EEIKELMRTV EELQKRNLKD SWLETSAVRR VEQETQRKLS HLQAELDEMY GKQIVQMKQE LINQHMSQIE ELKSQHKREM ENTLKSDTNA AISKEQVNLM NAAINELNVR LQETHAQKEE LKGELGVVLG EKSALQSQSN DLLEEVRFLR EQVQKARQTI AEQENRLSEA RKSLSTVEDL KAEIVAASES RKELELKHEA EITNYKIKLE MLEKEKNAVL DRMAESQEAE LERLRTQPLF SHEEELSKLK EDLEVEHRIN IEKLKDNLGI HYKQQIDGLQ NEMNRKMESM QCETDNLITQ QNQLILENSK LRDLQECLVN SKSEEMNLQI NELQKEIEIL KQEEKEKGTL EQEVQELQLK TEQLEKQLKE KEDDLQEKCA QLDAENNILK EEKRVLEDKL KMYSPSEQEE RSIAVDPSTS KLADSRWQKE VAMLRKETED LQQQCLYLNE EIEKQRNTFA FAEKNFEVNY QELQREYTCL LKIRDDLEAT QTKQALEYES KLRALEEELL SKRGNPXAPK GKSSGIFPSE TLEIGEVVEK DTTELMEKLE VTKREKLELS EKVSGLSEQL KQTHCTINSL SAEXRALKQE KEQLLLRCGE LELLANPSGT ENAAVCPVQM SSYQAGLVMG KVGDSGGSIS KISKDLAEES KPMIEDKIPF KESGREQLLL PTRAQEPSHA TVEPCESEKL QQELHALKAE QDDLRLQMEA QRICLFVVYS THADQVRAHM EKEREEALCS LKDELISAQQ KKIDELHKMH QCQLQNVKIQ ETGDEPLQVL IERLQKAVSE KCFHISKTLN NVFDECYTPL KCEMNIEEKE NSGVYTSQNQ SPELQEYRYE VQDFQESMQV LLGKVTEECR KLSGLQTRLG KIHEQQTDGV ALEFAEQNAA EEEAGLLSGC SQSALQSTDV SLESKVSSLP ASEKNRECER QVQELQSPVA AGQLQLTETE ASHRAEIECL QQRLEAASEA PVQPSLSIDS VVFKGSGAQK PVYCGSCLRE YVDGTAKFSD RFEVRQETNM VNLMEKQYQE RLEEEIAKVI VSMSIAFAQQ TELSRLSEGK ENTIQSEQAH TLCSQNKHQL NDITSQSQVG LQTFEATDKB FKEEFKPLSK ELGEYRKAVP LSSHDDLDDI LKSEEHGLAI SEEIFSKDET FIVRKSMHDE VLVSSMDTSR QLILNEQLED MRQELVRQYE EHQQATEMLR QAHMQQMERQ REDQEQLQEE IKRLNEQLTQ KSSIDTEHVV SERERVLLEE LEALKQLPLA GRKELCCELR HSSTQTQDGH DDQEVEEQTL KDKTLERSPE DALLDRNLSN ERYALKKANN RLLKILLEVV KTTSAAEETI GRHVLGILDR SSKGQTASSL LWRSEADASA TTCAPEDCAR AMDESIPSYP GTAIATHDSI WSKVTEEGAE LSQRLVRSGF AGPVIDPENE ELMLNISSRL QAAVEKLLEA ISETNTQLEH AKVTQTELMR ESFRQKQEAT ESLHCLEELR ERLQEESRAR EQLAEELNKA ESVIDGYSDE KTLFERQIQE KTDIIEHLEQ EVLCMNNRLQ ELESDQRRVE EERQLLCRQR EAMRAEAGPV EQQFLQETEK LMKEKLEVQC QAEKVRGDLQ KQVKALEIDV EEQVSRFIEL EQEKNAELTD LRQQSQALEK QLEKMRKFLD EQAIDREHER DVFQQEIQKL EHQLKAAPRI QPVSEHQARE VEQLTNHLKE KTDRCSELLL SKEQLQRDIQ ERNEEIEKLE CRVRELEQAL LASAEPFPKV EDQKRSGAVA ADPELSLEVQ LQAERDATDR KQKEITNLEE QLEQFREELE NKNDEVQELL MQLEIQRKES TTRLQELQQE NRLFKDEIEK LGFAMKESDS VSTRDQPMLF GKFAQLIQEK EIEIDRLNEQ FIKLQQQLKL TTDNKVIEEQ KEQIQDLETQ IERLMSEREH EKKQREEEVE QLTGVVEKLQ QEVVSTEQQR EGARTLPEDE ESFKHQLDKV TAEKLVLEQQ VETTNQVMTH MNNVLKEINF KMDQITQSLC NLNKECASNE ELPSLPKESV HMTVHELGSD NLQPEDAPAQ DVTKPLEKQT SLTRLQESPE ASRTQEIESL ASSVGAKDVE LTQCREQTET IQEQAQSETD RLQKKLTDLQ RSLEKFAAAL VSQVQMEAAQ EYVPFHQEKQ PVSSAPGSTD IQNANGLTGA STESLIPTVT LRLAEVESRV AEVHSGTMSE KLVGIVGGNA SETEKRVIEL QKLLEEAEER PEEGGEQSSR DGEVRESYMT SLQKDLGQVK DPLTEAKEKL SYSLEKEKRT GEQESREAPI PEPPSVEVGG CSGLTERTDK VSSSGNQTLQ ILLRDAAIQT DLQSESSQEE VRDTINQLTK KMEHIQELHA AEILDMESRH ILETESLKKE HYVAIQLLTK ECETLKEMTQ CLRCKEGSSI PELADSVAYQ SREVYSSDSE SDWGQSQGFD TAIEGREEGE TSADLFPKKI KGLVKAVHSE GMQVLSLSSP LCDDGEDRSI QQLSESWLKE RQAYLNTISS LKDLISKMQV RRETEVYDRC HLSDWRGELL LACQRVFIKE RSVLLATFQT ELTSLSTRDV DGLLNSLEQR IQEQGIEYHT AMDCLQKADR RSLLAEIEDL RAQINGGKMT LEREQGTEKS SQELLDCSMQ QKQSLEMQLE LSSLRDRAAE LQEQLSSEKM VVAELKSELA QAKLELGTTL KAQHKRLKEL EAFRSEVKEK TDEIHFLSDT LAREQKNSLE LQWALEKEKA RSGHHEEREK EELEDLKFSL EDQKRRNTQL NLLLEQQKQL LNESQQKIES QKMLHDAQLS EEQGRNLGLQ ALLESEQVRI QEMKSTLDKE RELYAQLQSR EDGGQPPPAL PSEDLLKELQ KQLEEKHSRI VELLSETEKY KLDSLQTRQQ MEKDRQVHQK TLQTEQEANT QGQKKMQELQ SKVEELQRQL QEKRQQVYKL DLEGKRLQGL MQEFQKQELE PEEKPGSRGL VDQNLNEPAT WNFTDDRTRN WVLQQKMGEA KDRNFTKLIE INGGELDHNH DLEMIRQTLQ HVASKLQHVA QKACSRLQFE TAGDDAFIWI QENIDGIILQ LQKLTGQPGD EHSLGPPSSS CGSLTESLMR QNTELTRLIN QLTEEKNTLR SIVIKLEELN RCYWHTGASR DCCSRFSFID PADIEAIIAS EKEVWNREKL SLQKALKRAE AKVYKLKAEL RNDALLRNLG PDTDHAALQK IYNKYLRASS FRKALIYQKK YLLLLLGGFQ ECEDVTLGVL ARMGGHLALK DSKTITNHPK AFSRFRSAVR VSIAISRMKF LVRRWQQVTS TSSININRDG FGLSPGIEKT DPFYHSPGGL ELYGEPRHTM YRSRFDLDYP RSLLPLQNRY PGTPGDLNSI SMASSQLHQY NPDKSLTDYV TRLEALRRRL GAIQSGSTTQ FHFGMRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 2, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.

Gene References into Functions

Nesprin-1alpha recruits Akap450 to the nuclear envelope (NE)independently of kinesin and that Akap450, but not other centrosomal proteins, is required for microtubule nucleation from the NE. PMID:28966089
AKAP9 and, by inference, the regulation of the microtubule network are critical for blood-testis barrier function and subsequent germ cell development during spermatogenesis PMID:26687990
AKAP9 is dispensable for T cell priming and migration into tissues and lymph nodes, but is required for T cell retention in tissues. PMID:26680259
We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain. PMID:25961040
Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and ciliogenesis. PMID:24648492
Mutations in Akap9 disrupt Sertoli cell maturation, gap and tight junctions and localization of zona occluden-1 and connexin43. PMID:23608191
in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation. PMID:22778270
Expression of Akap9 in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). PMID:20808911