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Recombinant Mouse A-kinase anchor protein 8-like (Akap8l)

Recombinant Mouse A-kinase anchor protein 8-like (Akap8l)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Akap8l

Purity

>85% (SDS-PAGE)

Target Names

Akap8l

Uniprot NO.

Q9R0L7

Alternative Names

Akap8l; Nakap; Nakap95A-kinase anchor protein 8-like; AKAP8-like protein; Neighbor of A-kinase-anchoring protein 95; Neighbor of AKAP95

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-642

Target Protein Sequence

MSYTGFVQGS ETTLQSTYCD TSAQPTCDYG YGTWNSGTNR GYENYGYGYG YGQDNTTNYG YGMATSHSWE MASSDTNANP SASGSASADS VLSRINQRLD MMPHLETDMI QGGVYGSGGG ERYDSYEACD SRAILSERDL YRSSYDYGEL DPEMEMAYEG QYDAYRDQFR MRGGDTFGPR AQGWARDARS GRPMASGYGR MWEDPMGARG QCMPGASRLP SLFSQNIIPE YGMFQGMRGG GAFSGGSRFG FGFGNGMKQM RRTWKTWTTA DFRTKKKKRK QGGSPDEPDS KATRTDCSDN SDSDNDEGTE GEAAEGTESA EAMEKGSRVD GEDEEGKEDG REEGKEDPEK GALTAQDESS QAKRKLQASK KSQDKQKKRQ RDRMVERIQF VCSLCKYRTF YEDEMGSHLD SKFHKEHFKY VGTKLPKQTA DFLQEYVTNK TKKTEELRKT VEDLDGLIQQ IYRDQDLTQE IAMEHFVKKV EAAHCAACDL FIPMQFGIIQ KHLKTMDHNR NRRLMMEQSK KSSLMVARSI LNNKLISKKL ERYLKGENPF TDNPEEEKEQ DEVEAGALDE GAPSEATELT EGVPAQPPVP LEPAPGTTTP PPPPPPEEEE SPVPLLGGAL QCQIRGIPGL DMEDDEEGGG GP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing.

Subcellular Location

Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm.

Protein Families

AKAP95 family

Database Links

UNIGENE: Mm.281005

STRING: 10090.ENSMUSP00000051389

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