Recombinant Mouse 14-3-3 protein gamma (Ywhag)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ywhag

Uniprot NO.

P61982

Alternative Names

Ywhag14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma; N-terminally processed]

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-247

Target Protein Sequence

MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Gene References into Functions

14-3-3gamma promotes surface expression of Best1 channel in astrocytes through direct interaction. PMID:29121962
This study found that in utero 14-3-3gamma-deficiency resulted in delays in neuronal migration as well as morphological defects. PMID:26297819
Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two. PMID:26198629
These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding. PMID:25047048
Ser(58) phosphorylation and Lys(49) acetylation of 14-3-3gamm occur in a coordinated time-dependent manner to regulate 14-3-3gamma homodimerization. PMID:25086053
overexpression of 14-3-3gamma led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins. PMID:21152247
Studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation. PMID:20628654
Data suggest that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease. PMID:20642453
The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes PMID:12176032
Nuclear poly-ADP-ribosylation of 14-3-3gamma was completely inhibited by the dose of the PARP-1 inhibitor 5-iodo-6-amino-1,2-benzopyrone that produced profound memory disturbances in maze learning tests PMID:12694396
the binding of 14-3-3gamma to Raf indicates the critical role of this protein in ischemia-induced apoptosis and the changes in signal transduction in astrocytes in culture. PMID:12730952
Data suggest that neuroglobin contributes to neuronal defensive machinery against oxidative injuries by regulating 14-3-3gamma expression. PMID:19574997