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Recombinant Mouse [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (Bckdk)

Recombinant Mouse [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (Bckdk)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Bckdk

Uniprot NO.

O55028

Alternative Names

Bckdk; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; mitochondrial; EC 2.7.11.4; Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

31-412

Target Protein Sequence

STSATDTHHV ELARERSKTV TSFYNQSAID VAAEKPSVRL TPTMMLYSGR SQDGSHLLKS GRYLQQELPV RIAHRIKGFR SLPFIIGCNP TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI QDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI TIANNDIDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRINPLFG HLDMHSGGQS GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.

Gene References into Functions

Results suggest that targeting mitochondrial BCKD kinase (BDK) as a pharmacological approach to mitigate the branched-chain amino acids (BCAAs) accumulation in metabolic diseases and heart failure. PMID:23716694
Tissue-specific translation of murine BCKDK mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region PMID:15302860
branched-chain a-keto acid dehydrogenase complex kinase plays an important role in conserving branched-chain amino acids by limiting their oxidation PMID:16875466

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Subcellular Location

Mitochondrion matrix. Mitochondrion.

Protein Families

PDK/BCKDK protein kinase family

Tissue Specificity

Ubiquitous.

Database Links

UNIGENE: Mm.425495

KEGG: mmu:12041

STRING: 10090.ENSMUSP00000070345

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