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Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A, isoform 2 (CDKN2A)

Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A, isoform 2 (CDKN2A)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CDKN2A

Uniprot NO.

O77618

Alternative Names

CDKN2ATumor suppressor ARF; Alternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p19ARF

Species

Monodelphis domestica (Gray short-tailed opossum)

Source

Yeast

Expression Region

1-155

Target Protein Sequence

MIRRVRVTVR VSRACRPHHV RIFVAKIVQA LCRASASINQ GTPFQVLLIV RKKRHRGRSG HDDGQCTPGS NPVAVRGGTQ HPRPDNPHPA SPRRCPGGLP GHSDAAPSGR GAAGCQGLLG SPACGPRRGT RTPPRGRIPA RGGEGRLNDT VQEAQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm.

Tissue Specificity

Ubiquitously expressed. In the testis, expressed in both somatic and germ cells. Not detected in premeiotic spermatogonia but expressed in both meiotic and postmeiotic cells. In primary tumors, low levels detected in melanocytic hyperplasias. Higher level

Database Links

UNIGENE: Mdm.219

KEGG: mdo:554242

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