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Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Recombinant Monodelphis domestica Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CDKN2A

Uniprot NO.

O77617

Species

Monodelphis domestica (Gray short-tailed opossum)

Source

Yeast

Expression Region

1-171

Target Protein Sequence

MGIVEKKEGG LERNRALFNS EGSCEGAKCG KEASMHTKHE SEESFSGEKL TEAAARGRTE VVTELLELGT NPNAVNRFGR SAIQVMMMGN VRLAAILLQY GAEPNTPDPT TLTLPVHDAA REGFLDTLML LHRAGARLDV RDSWGRLPVD LAEEQGHHLV VAYLREVVRD A
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Gene References into Functions

Variations confer impaired glucose- and tolbutamide-induced insulin release in middle-aged and young healthy subjects. PMID:17827400

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

CDKN2 cyclin-dependent kinase inhibitor family

Tissue Specificity

Expressed predominantly in lung and testis. In the testis, restricted to germ cells in the seminiferous epithelium. Not detected in premeiotic spermatogonia but high levels found in postmeiotic spermatids. In primary tumors, low levels detected in melanoc

Database Links

UNIGENE: Mdm.219

STRING: 13616.ENSMODP00000004687

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