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Recombinant Macaca fascicularis Repulsive guidance molecule A (RGMA)

Recombinant Macaca fascicularis Repulsive guidance molecule A (RGMA)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

RGMA

Purity

>85% (SDS-PAGE)

Target Names

RGMA

Uniprot NO.

Q9N0A6

Species

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Source

Yeast

Expression Region

177-433

Target Protein Sequence

PHLR TFTDRFQTCK VQGAWPLIDN NYLNVQVTNT PVLPGSAATA TSKLTIIFKN FQECVDQKVY QAEMDELPAA FVDGSKNGGD KHGANSLKIT EKVSGQHVEI RAKYIGTTIV VRQVGRYLTF AVRVPEEVVN AVEDWDSQGL YLCLRGCPLN QQIDFQAFHT NTEGTGARRL AAASPAPTAP ETFPYETAVA KCKEKLPVED LYYQACVFDL LTTGDVNFTL AAYYALEDVK MLHSNKDKLH LYERTRDLPG RAA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Repulsive guidance molecule (RGM) family

Database Links

UNIGENE: Mfa.9131

KEGG: mcf:101866018

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