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Recombinant Macaca fascicularis CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), partial

Recombinant Macaca fascicularis CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CDK5RAP2

Purity

>85% (SDS-PAGE)

Target Names

CDK5RAP2

Uniprot NO.

Q9BE52

Alternative Names

CDK5RAP2; QflA-15432CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48

Species

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Source

Yeast

Expression Region

1-862

Target Protein Sequence

MMDSVLEEDV TLLGTLSGCS GLVPNVPDDL DGINPDARLG NGVLSNVSEE TVSPTRARNM KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPAEHIY KTNIELKVEV ESLKRELQER ERLLIRASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VKAAQAELEK AFAGTETEKA LRLSLESKLS EMKKMHKGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL KEEKSQMASP DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK AREALQKAQT QEFQGSENYE AALSGKEALL TELRSQNLTK SAENHRLRRS IKKITQELSD LQQERERLEK DLEEAHREKS RGDCTIRDLR NEVEKLRNEV NERKKAMENR YKNLLSESSK KLHNQEQVIK HLTERTNHKD MLLQKFNEKD LEVIQQNHYL MTAEDLELRS EGLITEKCPS QQSPGSKTIF SKEEKQSSDY QELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNNIFAL RKQLERDVLS YQNLRRTLEE QISEIRRREE ESFSFYSDQT SYLSICLEEN NRFQVEHFSQ EELKKKVSDL IQLVKELYTD DQHLKKTIFD LSCMGFQGNG FPDRLVSTEQ TEIMKDLSKG GCKNGYLRHT EPKILESDGA HTPGCLEEGV FINLLAPLFN EKATLLLESR PDLLKVVREL LLGHLCLAEQ DVSGEHLGGK TEKTPKLHKK LFEQEKKLQN TMKLLQLSKR QEKVIFDQLV VTHKILRKAR GNLELRPGGA HPGTCSPSRP GS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. In complex with PDE4DIP, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis.

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton.

Database Links

UNIGENE: Mfa.6518

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