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Recombinant Kluyveromyces lactis Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial

Recombinant Kluyveromyces lactis Ubiquitin-like modifier-activating enzyme ATG7 (ATG7), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ATG7

Purity

>85% (SDS-PAGE)

Target Names

ATG7

Uniprot NO.

Q6CXW3

Alternative Names

ATG7; KLLA0A05137gUbiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7

Species

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

Source

Yeast

Expression Region

1-603

Target Protein Sequence

MLNDLKFSPA FKSFVDTSFF HELSRLKLEV FKLDSAEKEL FSALDLENIT SNTVSLSLRD DSFDPVLNNE AVTLKGSVLN FNTIESFKSC DKVKFIKEKG QQLLEQGLKN GLKECVRFYV ISFADLKKYK FYYWVCMPTF QSEGSSYEII STKSIEDGVK KDIWEQNSFI SCVVDGKIQE ASPQYLKVCQ KVIFKDFSRL KGIPAAVTKN FLTVWSQIST RNTYTICFLR DDNSSFAAEI RVTGSNTGCL KVSGWEKNGL GKLAPKSADL SSLMDPVKIA EQSIDLNLKL MKWRIAPDID LERIKNIKAL ILGSGTLGCY VARALLAWGT RHVTFVDNST VSFSNPVRQP LFNFEDCGRP KAEAASDSLK KIFPSVVSAG YQLEIPMIGH PVSNESKQRK DYEILDELIR THDVIFLLMD ARETRWLPSV LGRMHEKIVI NAALGFDSYL VMRHGNNNDN LGCYFCNDIV APSDSLTDRT LDQMCTVTRP GVALLAASQA VELLVTYLQP STNVLGSAPH QIRGFLNEFK TVKLETPAYQ HCCASNENVI LTLKENGWNF VKQALDDYKC VEQLSGLSKV QEEAELAIQE DISFDDDEEL SIE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.

Subcellular Location

Cytoplasm. Preautophagosomal structure.

Protein Families

ATG7 family

Database Links

KEGG: kla:KLLA0A05137g

STRING: 284590.XP_451226.1

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