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Recombinant Influenza C virus Non-structural protein 1 (NS)

Code
MSDS
MSDS
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
NS
Uniprot NO.
Species
Influenza C virus (strain C/Ann Arbor/1/1950)
Source
Yeast
Expression Region
1-246
Target Protein Sequence
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS FAPRTWEDAI KDGELLFNGT ILQTESPTMT PASVEMKGKK FPIDFAPSNI APIGQNPIYL SPCIPNFDGN VWEATMYHHR GATLTKTMNC NCFQRTIWCH PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ VAGIETGIRK CFRCIKSGFV MATDEISLTI LQSIKSGAQL DPYWGNEKPD IDKTEAYMLS LREAGP
Protein Length
full length protein
Tag Info
N-terminal His-tagged/Tag-Free
Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Description

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Target Background

Function
Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the upregulation of the splicing of viral mRNAs.
Gene References into Functions
  1. The introduction of premature translational termination into the NS gene, which blocked the synthesis of the C/NS1 and C/NS2 proteins, drastically reduced the splicing of NS mRNA, raising the possibility that C/NS1 or C/NS2 enhances viral mRNA splicing. PMID:20007279

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Subcellular Location
Host cytoplasm. Host nucleus.
Protein Families
Influenza C viruses NS1 family
Database Links

KEGG: vg:3077236

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