Recombinant Influenza A virus Polymerase acidic protein (PA), partial

Code
MSDS
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Source
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PA
Uniprot NO.
Species
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
Source
Yeast
Expression Region
1-716
Target Protein Sequence
MEDFVRQCFN PMIVELAEKA MKEYGEDPKI ETNKFAAICT HLEVCFMYSD FHFINELGES VIIESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTRA EKPKFLPDLY DYKENRFVEI GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET IEERFEITGT MRRLADYSLP PNFSSLENFR AYVDGFEPNG CIESKLSQMS KEVNTRIEPF SKTTPRPLRT PGGPPCYQRS KFLLMDALKF SIEDPSHEGE GIPLYDAIKC MKTFFGWKEP NIVKPHEKGI NPNYLQAWKQ VLAELQDLEN EEKIPKTKNM KKTSQLKWAL GENMAPEKVD FEDCKDISDL KQYDSDEPET RSLASWIQSE FNKACELTDS SWIELDEIGE DVAPIEHIAS MRRNYFTAEV SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHNWEKY CVLEIGDMLL RTAVGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMTEAES SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY ASPQLEGFSA ESRKILLIVQ ALRDNLEPGT FDIGGLYESI EECLINDPWV LLNASWFNSF LTHALK
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
Storage
The shelf life of liquid-form form is 6 months around at -20°C/-80°C.
The shelf life of lyophilized form is 12 months around at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Description

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Target Background

Function
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Subcellular Location
Host cytoplasm. Host nucleus.
Protein Families
Influenza viruses PA family

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