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Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL)

Recombinant Human herpesvirus 2 Envelope glycoprotein L (gL)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

P28278

Alternative Names

gL; UL1Envelope glycoprotein L; gL

Species

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)

Source

Yeast

Expression Region

17-224

Target Protein Sequence

AWGG SQATEYVLRS VIAKEVGDIL RVPCMRTPAD DVSWRYEAPS VIDYARIDGI FLRYHCPGLD TFLWDRHAQR AYLVNPFLFA AGFLEDLSHS VFPADTQETT TRRALYKEIR DALGSRKQAV SHAPVRAGCV NFDYSRTRRC VGRRDLRPAN TTSTWEPPVS SDDEASSQSK PLATQPPVLA LSNAPPRRVS PTRGRRRHTR LRRN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.

Gene References into Functions

HIV-1 produced from CD4+ T cells bears HSV-2 receptor HVEM and can bind to and enter HSV-2-infected epithelial cells depending on HVEM-gD interaction and the presence of gB/gH/gL. PMID:28809154
This study supports the concept that gB is the herpes simplex virus fusogen and its activity is regulated by gH/gL. PMID:23443004
Determined is the crystal structure of the glycoprotein H ectodomain bound to glycoprotein L from herpes simplex virus 2. PMID:20601960
Epitope mapping identified three distinc antigenic sites on gL (A, B, and C), and of most importance, the MAbs with biological activity mapped to sites B and C of gL2 (residues 191 to 210). PMID:16501070
results show that gL is not merely required for gH transport but is also necessary for folding & function of the complex; results highlight several key gH residues: R39, Y41, W42, and D44 for gH transport and L66 and L72 for gH/gL structure and function PMID:17344290

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Subcellular Location

Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network.

Protein Families

Herpesviridae glycoprotein L family

Database Links

KEGG: vg:1487292

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