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Recombinant Human cytomegalovirus Protein UL76 (UL76)

Recombinant Human cytomegalovirus Protein UL76 (UL76)

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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

UL76

Uniprot NO.

P16725

Species

Human cytomegalovirus (strain AD169) (HHV-5) (HCMV)

Source

Yeast

Expression Region

1-325

Target Protein Sequence

MPSGRGDDAD STGNALRRLP HVRKRIGKRK HLDIYRRLLR VFPSFVALNR LLGGLFPPEL QKYRRRLFIE VRLSRRIPDC VLVFLPPDSG SRGIVYCYVI EFKTTYSDAD DQSVRWHATH SLQYAEGLRQ LKGALVDFDF LRLPRGGGQV WSVVPSLVFF QQKADRPSFY RAFRSGRFDL CTDSVLDYLG RRQDESVAHL LAATRRRLLR TARGKRAALP RARASAVAGG RGGDNARRGL ARGRAHGPGA QTVSASGAQG SGSQGADLLR GSRRARVRGG GAVEPAVRAR RRTVAADAAT TTVSSAFFVP RDRRGRSFCR PTRSL

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL76 supposedly acts on this process through its effect on host nucleoli. Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclinB/CDK1.

Subcellular Location

Virion. Host nucleus. Host nucleus, host nucleolus.

Protein Families

Herpesviridae UL24 family

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