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Recombinant Human Zinc finger and BTB domain-containing protein 38 (ZBTB38), partial

Recombinant Human Zinc finger and BTB domain-containing protein 38 (ZBTB38), partial

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ZBTB38

Uniprot NO.

Q8NAP3

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-1195

Target Protein Sequence

MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV LAASSLYFKN IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR QETVTDLAAA GKKLGISFLE DLTDRNFSNS PGPYVFCITE KGVVKEEKNE KRHEEPAITN GPRITNAFSI IETENSNNMF SPLDLRASFK KVSDSMRTAS LCLERTDVCH EAEPVRTLAE HSYAVSSVAE AYRSQPVREH DGSSPGNTGK ENCEALAAKP KTCRKPKTFS IPQDSDSATE NIPPPPVSNL EVNQERSPQP AAVLTRSKSP NNEGDVHFSR EDENQSSDVP GPPAAEVPPL VYNCSCCSKA FDSSTLLSAH MQLHKPTQEP LVCKYCNKQF TTLNRLDRHE QICMRSSHMP IPGGNQRFLE NYPTIGQNGG SFTGPEPLLS ENRIGEFSST GSTLPDTDHM VKFVNGQMLY SCVVCKRSYV TLSSLRRHAN VHSWRRTYPC HYCNKVFALA EYRTRHEIWH TGERRYQCIF CLETFMTYYI LKNHQKSFHA IDHRLSISKK TANGGLKPSV YPYKLYRLLP MKCKRAPYKS YRNSSYENAR ENSQMNESAP GTYVVQNPHS SELPTLNFQD TVNTLTNSPA IPLETSACQD IPTSANVQNA EGTKWGEEAL KMDLDNNFYS TEVSVSSTEN AVSSDLRAGD VPVLSLSNSS ENAASVISYS GSAPSVIVHS SQFSSVIMHS NAIAAMTSSN HRAFSDPAVS QSLKDDSKPE PDKVGRFASR PKSIKEKKKT TSHTRGEIPE ESNYVADPGG SLSKTTNIAE ETSKIETYIA KPALPGTSTN SNVAPLCQIT VKIGNEAIVK RHILGSKLFY KRGRRPKYQM QEEPLPQGND PEPSGDSPLG LCQSECMEMS EVFDDASDQD STDKPWRPYY NYKPKKKSRQ LKKMRKVNWR KEHGNRSPSH KCKYPAELDC AVGKAPQDKP FEEEETKEMP KLQCELCDGD KAVGAGNQGR PHRHLTSRPY ACELCAKQFQ SPSTLKMHMR CHTGEKPYQC KTCGRCFSVQ GNLQKHERIH LGLKEFVCQY CNKAFTLNET LKIHERIHTG EKRYHCQFCF QRFLYLSTKR NHEQRHIREH NGKGYACFQC PKICKTAAAL GMHQKKHLFK SPSQQEKIGD VCHENSNPLE NQHFIGSEDN DQKDNIQTGV ENVVL

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons.

Gene References into Functions

Results show that ZBTB38 knockdown significantly inhibits autophagic expression and downregulates RB1CC1 expression in SHSY5Y cells. Its overexpression upregulates RB1CC1 expression and enhances autophagy in spinal cord injury mice model. PMID:30075197
rescue of Zbtb38 can alleviate secondary damage of spinal cord through inhibition of ER stress-associated apoptosis, which provides a novel therapeutic regimen that targeting Zbtb38 may promote functional recovery of spinal cord for patients with SCI. PMID:28514761
ZBTB38 regulates replication efficiency by controlling MCM10 transcription. PMID:24726359
The nonsynonymous SNP (rs16851435:T > G,p.Ser319Ala) of ZBTB38 contributed to susceptibility of idiopathic short stature in the Chinese Han population. PMID:23302005
Alternative splicing of human height-related zinc finger and BTB domain-containing 38 gene through Alu exonization PMID:21188497
Observational study of gene-disease association. (HuGE Navigator) PMID:20846217
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID:20966902
Observational study of gene-disease association. (HuGE Navigator) PMID:20546612
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID:20189936
ZBTB38 binds methylated methylated CpGs in vitro and in vivo and represses transcrption. PMID:16354688
There was strongest association with SNPs in the ZBTB38 gene and adult human height. PMID:18391951
Observational study of gene-disease association. (HuGE Navigator) PMID:19266077