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Recombinant Human Zinc finger CW-type PWWP domain protein 1 (ZCWPW1)

Recombinant Human Zinc finger CW-type PWWP domain protein 1 (ZCWPW1)

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ZCWPW1

Uniprot NO.

Q9H0M4

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-648

Target Protein Sequence

MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs). Essential for male fertility and spermatogenesis. Required for meiosis prophase I progression in male but not in female germ cells.

Gene References into Functions

rs1476679 polymorphism in ZCWPW1 is associated with late-onset Alzheimer's disease. PMID:26958812
PILRB and GATS expression levels, within the ZCWPW1 locus, were associated with Alzheimer's disease status. PMID:26919393
Of those 394 variants, 34 showed strong evidence of regulatory function (RegulomeDB score <3), and only 3 of them were genome-wide significant SNPs (ZCWPW1/rs1476679, CLU/rs1532278 and ABCA7/rs3764650). PMID:24743338

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Subcellular Location

Nucleus. Chromosome.

Tissue Specificity

Testis.

Database Links

HGNC: 23486

UNIGENE: Hs.105191

KEGG: hsa:55063

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