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Recombinant Human Voltage-dependent anion-selective channel protein 3 (VDAC3), partial

Recombinant Human Voltage-dependent anion-selective channel protein 3 (VDAC3), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

VDAC3

Purity

>85% (SDS-PAGE)

Target Names

VDAC3

Uniprot NO.

Q9Y277

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene References into Functions

The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count. PMID:28431403
This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID:28916538
VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space. PMID:26806159
channel gating of VDAC3 might be controlled by redox sensing under physiological conditions PMID:26407725
observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells PMID:25171321
a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry. PMID:23388454
VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID:22935710
VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS production. PMID:20138821
VDAC3 is a novel target for protein S-nigrosylation in spermatozoa. PMID:17683036