Recombinant Human Transcription factor 12 (TCF12)

1. These results identify HEB as a critical regulator of human mesodermal and hematopoietic specification. PMID:28803914
2. HDAC1 promoted migration and invasion of gallbladder tumor cells by binding with TCF12 to promote epithelial mesenchymal transformation. PMID:27092878
3. Study describes the identification of three large inherited intragenic exon deletions in TCF12 using whole-genome sequencing and one large inherited duplication using targeted TCF12 sequencing in patients with craniosynostosis. PMID:27158814
4. Heb expression is regulated by Med19 in breast cancer cells. PMID:27572702
5. enforced expression of transcription factor 12 suppressed cell proliferation, migration, and invasion in vitro and inhibited tumor growth in vivo. In conclusion, transcription factor 12 protein may be a novel molecule which plays a critical role in prostate cancer progression and patients' prognosis, suggesting it might be a promising therapeutic target for prostate cancer therapy PMID:28651494
6. HEB may be involved in GBM cell proliferation, as HEB silencing reduced proliferation in cells cultured as monolayers or neurospheres. Furthermore, the results suggested a potential role for HEB in the maintenance of GBM stem cells, as HEB silencing affected the differentiation capacity of cells. PMID:27779678
7. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12 in myeloid leukemia. PMID:26671595
8. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing. PMID:25271085
9. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type PMID:26068201
10. several familial cases of coronal synostosis associated with mutations in TCF12 PMID:24736737
11. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1. PMID:23354436
12. the CD91/IKK/NF-kappaB signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion PMID:23386606
13. TCF12 functioned as a transcriptional repressor of E-cadherin and its overexpression was significantly correlated with the occurrence of CRC metastasis. PMID:22130667
14. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint. PMID:20798984
15. T cell development is impaired by Id2, most likely by sequestering HEB, whereas NK cell development is promoted by increasing a pool of CD1a-CD5+ NK cell progenitors, which together with IL-15 differentiate into mature NK cells PMID:20483740
16. two alternative acceptor sites for mRNA splicing yield two distinguishable transcripts (HTF4a and HTF4b) which differ in their 5' untranslated region but share identical coding sequences. PMID:12826747
17. CBFA2T3 interacts with ZNF652 to repress HEB expression, and in addition CBFA2T3 interacts with the HEB protein to inhibit its activator function. PMID:18456661
18. The DNA binding profile of the E-protein HEB was grossly rearranged upon expression of AML1/ETO, and the fusion protein was found to co-localize with both AML1 and HEB on many of its regulated targets PMID:19043539

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HGNC: 11623

UNIGENE: Hs.511504

KEGG: hsa:6938

STRING: 9606.ENSP00000331057

OMIM: 600480