Recombinant Human Thrombospondin-2 (THBS2), partial

1. TWIST2 induces miR-221-3p expression and consequently suppresses its direct target, THBS2, in lymphatic metastasis cervical cancer. PMID:29242498
2. THBS2 could be considered as a novel prognostic marker in colorectal cancer. PMID:27632935
3. By testing for THBS2 and another marker, CA19-9, researchers identified blood samples from patients with the disease with 98% specificity and 87% sensitivity. PMID:28739842
4. the combination of THBS2 and CA19-9 yielded a sensitivity of 87% for pancreatic ductal adenocarcinoma in the phase 2b study. PMID:28701476
5. Study found that 2 single nucleotide polymorphisms (rs6422747 and rs6422748) in the THBS2 gene were associated with susceptibility of intervertebral disc degeneration (IDD) but not severity of IDD in a Chinese Han population; results indicated that THBS2 gene polymorphisms might be the risk factors for IDD. PMID:29480856
6. TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. PMID:28122633
7. we report microRNA-135b (miR-135b), a key regulator of the malignancy, highly expressed in the RC component and promoting MLS cell invasion in vitro and metastasis in vivo through the direct suppression of thrombospondin 2 (THBS2). PMID:27157622
8. High THBS2 expression is associated with lung cancer. PMID:27513329
9. STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis PMID:28216224
10. the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis. PMID:28039493
11. THBS2 and THBS4 mRNA are overexpressed in gastric cancer in a Southeast Chinese population. PMID:27160021
12. The level of THBS2 in differentiating stem cells, influences chondrogenic differentiation potential. PMID:26235673
13. THBS2 protein, human is predicting lymph node metastases in OSCC, overall survival and disease-free survival. PMID:24764155
14. Study suggests THBS2 is aberrantly expressed in gastric cancer and plays a critical role in cancer progression. PMID:25262009
15. No association was observed between the THBS2 3' untranslated region polymorphism and coronary artery disease risk. PMID:25976449
16. THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma. PMID:24708169
17. Patients whose MPM tissues expressed elevated mRNA levels of BIRC5, DSP, NME2, and THBS2 showed a statistically significant shorter overall survival. PMID:25771974
18. Variants within the thrombospondin 2 (THBS2) gene are not associated with Achilles tendinopathy PMID:23875975
19. Although no SNPs in THBS2 were associated with lumbar spinal stenosis, two haplotypes were significantly associated with disease progression in the Korean population, whereas another haplotype may play a protective role. PMID:23807322
20. TSP-2 is a potentially useful biomarker for assessment of disease severity and prognosis in HFrEF. PMID:24500070
21. Estrogen receptor alpha in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3. PMID:24374826
22. TSP-2 haschondrogenic effects on chondroprogenitor cells via PKCA ERK, p38/MAPK, and Notch signaling pathways. PMID:23843355
23. Upregulation of TSP-2 may be a protective mechanism against inflammation and angiogenesis associated with proliferative diabetic retinopathy (PDR). PMID:23387388
24. TSP2 is down-regulated at PCa tissues and cell lines, especially at stroma compartment, which could be related to prostate cancer progression. PMID:23470460
25. TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis. PMID:22308237
26. Calcific aortic stenosis in associated with upregulation of TSP-2 expression, and inactivation of Akt and NF-kappaB. PMID:22035575
27. Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 PMID:21949402
28. In patients with preeclampsia, we demonstrated 1.7-fold higher tsp-2 compared with control group. PMID:21682699
29. Single-nucleotide polymorphism in THBS2 is associated with coronary atherosclerosis. PMID:20485444
30. LRP1 and TSP2 stimulate Notch activity by driving trans-endocytosis of the Notch ectodomain into the signal-sending cell PMID:20472562
31. the thrombospondin gene 2 T>G single nucleotide polymorphism is decreased only in plaque erosion, with no difference in frequency between other coronary disease and controls PMID:19631562
32. Normal human adult corneal keratocytes have mRNA for this protein. PMID:11943589
33. inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism PMID:12058057
34. All adrenal tissues (control adrenals, nonfunctional adenomas and ACTH-dependent aldosterone-producing adenomas) expressed both TSP1 and TSP2 mRNAs.both TSP1 and TSP2 mRNAs. Correlated closely with the expression of ACTH receptor. PMID:12358136
35. Homozygosity for the THBS-2 variant allele is significantly associated with a lower risk of premature myocardial infarction. PMID:12482844
36. Decreased thrombospondin-2 expression is associated with human salivary gland carcinomas PMID:12824879
37. Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling PMID:12861025
38. The 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2 was discribed. PMID:16186819
39. biophysical analysis of roles of signature domains of thrombospondin-4 and thrombospondin-2 in calcium binding, fine structure, and inter-modular interactions PMID:16246837
40. Gene-expression changes in human evolution that involve specific brain regions, including portions of cerebral cortex. PMID:17182969
41. TSP1 and TSP2, together with the VLDLR, initiate a nonapoptotic pathway for maintenance of the normal adult vascular endothelium in a quiescent state. PMID:18032585
42. TSP-2 was inconsistently expressed in uterine fibroids. PMID:18089612
43. regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH. PMID:18455130
44. The variant allele of THBS2 is a risk factor for TAA in hypertensive patients, whereas the variant alleles of HSPA8, GPX1, AGT, and TNF are protective against this condition. PMID:18600213
45. Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain. PMID:18682400
46. TSP-2 was found to be present in some, but not all, annulus cells of the human annulus and the mouse annulus. PMID:18718009
47. The expression of metastasis inhibitor genes PTEN and thrombospondin 2 was down-regulated in the supraglottic carcinoma tissue with lymph node metastasis. PMID:18720079
48. A significant correlation between microvessel density and the expression of trombospondin-2 (p=0.009) was found. PMID:18955754
49. When TSP-2 expression was reduced in tumor- derived pancreatic stellate cells using selective siRNAs, pancreatic cancer cell invasion was inhibited. PMID:19592030

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HGNC: 11786

UNIGENE: Hs.371147

KEGG: hsa:7058

STRING: 9606.ENSP00000355751

OMIM: 188061