Recombinant Human Teneurin-1 (ODZ1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ODZ1

Purity

>85% (SDS-PAGE)

Target Names

TENM1

Uniprot NO.

Q9UKZ4

Alternative Names

TENM1; ODZ1; TNM1; Teneurin-1; Ten-1; Protein Odd Oz/ten-m homolog 1; Tenascin-M1; Ten-m1; Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain; IDten-1; Ten-1 ICD); Teneurin C-terminal-associated peptide; TCPA-1; Ten-1 extracellular domain; Ten-1 ECD)]

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer.; Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking.; Induces gene transcription activation.

Gene References into Functions

Taken together, the results indicate that distinct pathways are involved in papillary thyroid cancer progression, and TENM1 is a potential marker of cancer progression. PMID:28004221
ODZ1, a protein that participates in the embryonic development of the brain, is also involved in cancer progression by promoting the growth and invasion capabilities of GSCs via a transcriptional pathway that induces the expression of RhoA and activation of downstream ROCK. PMID:27641332
Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases PMID:27040985
Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW] PMID:26485751
This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes TENM1. PMID:25666757
Studies indicate that teneurin-1 has been suggested as a candidate target gene for X-lined mental retardation. PMID:25152333
The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB. PMID:25648896
Subsequent analysis showed that the deletion in both cousins was identical and involved the whole SH2D1A gene and a part of the adjacent ODZ1 gene. PMID:22271700
Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID:21651764
teneurin-1 plays a role in intracellular signaling PMID:15777793

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Subcellular Location

Cell membrane; Single-pass membrane protein.; [Ten-1 intracellular domain]: Nucleus. Nucleus speckle. Nucleus matrix. Cytoplasm, cytoskeleton.; [Teneurin C-terminal-associated peptide]: Nucleus. Cytoplasm. Cell membrane.

Protein Families

Tenascin family, Teneurin subfamily

Tissue Specificity

Expressed in fetal brain.

Database Links

HGNC: 8117

UNIGENE: Hs.23796

KEGG: hsa:10178

STRING: 9606.ENSP00000403954

OMIM: 300588

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